| UniProt Protein Function: | CENPN: Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 16q23.2 Cellular Component: nucleoplasm; nucleus; cytosol Biological Process: mitosis; nucleosome assembly; DNA replication-independent nucleosome assembly at centromere; mitotic cell cycle; chromosome segregation |
| NCBI Summary: | The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q96H22 |
| NCBI GenInfo Identifier: | 308153423 |
| NCBI Gene ID: | 55839 |
| NCBI Accession: | Q96H22.2 |
| UniProt Secondary Accession: | Q96H22,Q9NZ83, A8MZE6, B3KN53, B4DJD1, B4DPY7, C9JJM5 D3DUK8, E7ES30, E7ETS3, |
| UniProt Related Accession: | Q96H22 |
| Molecular Weight: | 35,556 Da |
| NCBI Full Name: | Centromere protein N |
| NCBI Synonym Full Names: | centromere protein N |
| NCBI Official Symbol: | CENPN |
| NCBI Official Synonym Symbols: | BM039; CENP-N; ICEN32; C16orf60 |
| NCBI Protein Information: | centromere protein N; interphase centromere complex protein 32 |
| UniProt Protein Name: | Centromere protein N |
| UniProt Synonym Protein Names: | Interphase centromere complex protein 32 |
| Protein Family: | Centromere protein |
| UniProt Gene Name: | CENPN |
| UniProt Entry Name: | CENPN_HUMAN |
