Anti-CENPK Antibody (CAB7627)
- SKU:
- CAB7627
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CENPK Antibody |
抗体コード: | CAB7627 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human CENPK (NP_071428.2). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human |
ポジティブサンプル: | HeLa, SKOV3, 293T |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-269 of human CENPK (NP_071428.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MNQE DLDP DSTT DVGD VTNT EEEL IREC EEMW KDME ECQN KLSL IGTE TLTD SNAQ LSLL IMQV KCLT AELS QWQK KTPE TIPL TEDV LITL GKEE FQKL RQDL EMVL STKE SKNE KLKE DLER EQRW LDEQ QQIM ESLN VLHS ELKN KVET FSES RIFN ELKT KMLN IKEY KEKL LSTL GEFL EDHF PLPD RSVK KKKK NIQE SSVN LITL HEML EILI NRLF DVPH DPYV KISD SFWP PYVE LLLR NGIA LRHP EDPT RIRL EAFH Q |
遺伝子ID: | 64105 |
Uniprot: | Q9BS16 |
セルラーロケーション: | Chromosome, Nucleus, centromere, kinetochore |
計算された分子量: | 31kDa |
観察された分子量: | 37kDa |
同義語: | CENPK, AF5alpha, CENP-K, FKSG14, P33, Solt |
バックグラウンド: |
UniProt Protein Function: | CENPK: Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Acts in coordination with CASC5/KNL1 to recruit the NDC80 complex to the outer kinetochore. Chromosomal aberrations involving CENPK are a cause of acute leukemias. Translocation t(5;11)(q12;q23) with MLL. Belongs to the CENPK family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 5q12.3 Cellular Component: cytosol; nucleoplasm Molecular Function:protein binding Biological Process: DNA replication-independent nucleosome assembly at centromere; sister chromatid cohesion |
NCBI Summary: | CENPK is a subunit of a CENPH (MIM 605607)-CENPI (MIM 300065)-associated centromeric complex that targets CENPA (MIM 117139) to centromeres and is required for proper kinetochore function and mitotic progression (Okada et al., 2006 [PubMed 16622420]).[supplied by OMIM, Mar 2008] |
UniProt Code: | Q9BS16 |
NCBI GenInfo Identifier: | 74732954 |
NCBI Gene ID: | 64105 |
NCBI Accession: | Q9BS16.1 |
UniProt Secondary Accession: | Q9BS16,Q9H4L0, |
UniProt Related Accession: | Q9BS16 |
Molecular Weight: | 31,655 Da |
NCBI Full Name: | Centromere protein K |
NCBI Synonym Full Names: | centromere protein K |
NCBI Official Symbol: | CENPK |
NCBI Official Synonym Symbols: | P33; Solt; CENP-K; FKSG14; AF5alpha |
NCBI Protein Information: | centromere protein K |
UniProt Protein Name: | Centromere protein K |
UniProt Synonym Protein Names: | Interphase centromere complex protein 37; Protein AF-5alpha; p33 |
Protein Family: | Centromere protein |
UniProt Gene Name: | CENPK |
UniProt Entry Name: | CENPK_HUMAN |
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