Anti-CELA3B Antibody (CAB13714)
- SKU:
- CAB13714
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CELA3B Antibody |
| 抗体コード: | CAB13714 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Rat pancreas |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 80-190 of human CELA3B (NP_031378.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | TYQV VLGE YDRA VKEG PEQV IPIN SGDL FVHP LWNR SCVA CGND IALI KLSR SAQL GDAV QLAS LPPA GDIL PNET PCYI TGWG RLYT NGPL PDKL QEAL LPVV DYEH CSR |
| 遺伝子ID: | 23436 |
| Uniprot: | P08861 |
| セルラーロケーション: | |
| 計算された分子量: | 29kDa |
| 観察された分子量: | 29kDa |
| 同義語: | CELA3B, CBPP, ELA3B |
| バックグラウンド: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. |
| UniProt Protein Function: | CELA3B: Efficient protease with alanine specificity but only little elastolytic activity. Belongs to the peptidase S1 family. Elastase subfamily. |
| UniProt Protein Details: | Protein type:EC 3.4.21.70; Protease Chromosomal Location of Human Ortholog: 1p36.12 Molecular Function:peptidase activity; serine-type endopeptidase activity Biological Process: cholesterol metabolic process; proteolysis |
| NCBI Summary: | Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Unlike other elastases, elastase 3B has little elastolytic activity. Like most of the human elastases, elastase 3B is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. Elastase 3B preferentially cleaves proteins after alanine residues. Elastase 3B may also function in the intestinal transport and metabolism of cholesterol. Both elastase 3A and elastase 3B have been referred to as protease E and as elastase 1, and excretion of this protein in fecal material is frequently used as a measure of pancreatic function in clinical assays. [provided by RefSeq, May 2009] |
| UniProt Code: | P08861 |
| NCBI GenInfo Identifier: | 317373457 |
| NCBI Gene ID: | 23436 |
| NCBI Accession: | P08861.3 |
| UniProt Secondary Accession: | P08861,P11423, Q5VU28, Q5VU29, Q5VU30, B2RE44, |
| UniProt Related Accession: | P08861 |
| Molecular Weight: | 29,263 Da |
| NCBI Full Name: | Chymotrypsin-like elastase family member 3B |
| NCBI Synonym Full Names: | chymotrypsin-like elastase family, member 3B |
| NCBI Official Symbol: | CELA3B |
| NCBI Official Synonym Symbols: | E1; CBPP; EL-1; ELA3B |
| NCBI Protein Information: | chymotrypsin-like elastase family member 3B; elastase 1; protease E; elastase-3B; proteinase E; elastase IIIB; fecal elastase 1; pancreatic elastase 1; elastase 3B, pancreatic; pancreatic endopeptidase E; cholesterol-binding pancreatic protease |
| UniProt Protein Name: | Chymotrypsin-like elastase family member 3B |
| UniProt Synonym Protein Names: | Elastase IIIB; Elastase-3B; Protease E |
| Protein Family: | Chymotrypsin-like elastase family |
| UniProt Gene Name: | CELA3B |
| UniProt Entry Name: | CEL3B_HUMAN |
 | Western blot analysis of extracts of rat pancreas, using CELA3B antibody (CAB13714) at 1:3000 dilution. |
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