Anti-CDY1B Antibody (CAB15577)
- SKU:
- CAB15577
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CDY1B Antibody |
| 抗体コード: | CAB15577 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human CDY1B (NP_001003895.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse testis, Rat testis |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 60-320 of human CDY1B (NP_001003895.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EKQK KLTW TTTS RIFS NNAR RRTS RSTK ANYS KNSP KTPV TDKH HRSK NRKL FAAS KNVR RKAA SILS DTKN MEII NSTI ETLA PDSP FDHK TVSG FQKL EKLD PIAA DQQD TVVF KVTE GKLL RDPL SRPG AEQT GIQN KTQI HPLM SQMS GSVT ASMA TGSA TRKG IVVL IDPL AANG TTDM HTSV PRVK GGQR NITD DSRD QPFI KKMH FTIR LTES ASTY RDIV VKKE DGFT QIVL STRS TEKN ALNT EVIK EIVN A |
| 遺伝子ID: | 253175 |
| Uniprot: | Q9Y6F8 |
| セルラーロケーション: | Nucleus |
| 計算された分子量: | 60kDa/62kDa |
| 観察された分子量: | 60kDa |
| 同義語: | CDY1B, CDY |
| バックグラウンド: | This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. |
| UniProt Protein Function: | CDY1: Has histone acetyltransferase activity, with a preference for histone H4. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Acetyltransferase; EC 2.3.1.48 Chromosomal Location of Human Ortholog: Yq11.23 Cellular Component: nucleus Molecular Function:methylated histone residue binding Biological Process: spermatogenesis Disease: Spermatogenic Failure, Y-linked, 2 |
| NCBI Summary: | This gene encodes a protein containing a chromodomain and a histone acetyltransferase catalytic domain. Chromodomain proteins are components of heterochromatin-like complexes and can act as gene repressors. This protein is localized to the nucleus of late spermatids where histone hyperacetylation takes place. Histone hyperacetylation is thought to facilitate the transition in which protamines replace histones as the major DNA-packaging protein. The human chromosome Y has two identical copies of this gene within a palindromic region; this record represents the more centromeric copy. Chromosome Y also contains a pair of closely related genes in another more telomeric palindrome as well as several related pseudogenes. Two protein isoforms are encoded by transcript variants of this gene. Additional transcript variants have been described, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y6F8 |
| NCBI GenInfo Identifier: | 20138089 |
| NCBI Gene ID: | 253175 |
| NCBI Accession: | Q9Y6F8.1 |
| UniProt Secondary Accession: | Q9Y6F8,O14600, A2RUK1, |
| UniProt Related Accession: | Q9Y6F8 |
| Molecular Weight: | 62,017 Da |
| NCBI Full Name: | Testis-specific chromodomain protein Y 1 |
| NCBI Synonym Full Names: | chromodomain Y-linked 1B |
| NCBI Official Symbol: | CDY1B |
| NCBI Official Synonym Symbols: | CDY |
| NCBI Protein Information: | testis-specific chromodomain protein Y 1 |
| UniProt Protein Name: | Testis-specific chromodomain protein Y 1 |
| Protein Family: | Testis-specific chromodomain protein |
| UniProt Gene Name: | CDY1 |
| UniProt Entry Name: | CDY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDY1B antibody (CAB15577) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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