Anti-CDON Antibody (CAB15830)
- SKU:
- CAB15830
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| 抗体名: | Anti-CDON Antibody |
| 抗体コード: | CAB15830 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CDON (NP_001230526.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, NIH/3T3 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 520-720 of human CDON (NP_001230526.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | FETN TKAE TVTL PDAA QNDD RSKR DGSE TGLL SSFP VKVH PSAV ESAP EKNA SGIS VPDA PIIL SPPQ THTP DTYN LVWR AGKD GGLP INAY FVKY RKLD DGVG MLGS WHTV RVPG SENE LHLA ELEP SSLY EVLM VARS AAGE GQPA MLTF RTSK EKTA SSKN TQAS SPPV GIPK YPVV SEAA NNNF GVVL TDSS RHSG V |
| 遺伝子ID: | 50937 |
| Uniprot: | Q4KMG0 |
| セルラーロケーション: | Cell membrane, Single-pass membrane protein |
| 計算された分子量: | 136kDa/139kDa |
| 観察された分子量: | 150kDa |
| 同義語: | CDON, CDO, CDON1, HPE11, ORCAM |
| バックグラウンド: | This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. |
| UniProt Protein Function: | CDON: Component of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells. Promotes differentiation of myogenic cells. Defects in CDON are the cause of holoprosencephaly type 11 (HPE11). HPE11 is a structural anomaly of the brain, in which the developing forebrain fails to correctly separate into right and left hemispheres. Holoprosencephaly is genetically heterogeneous and associated with several distinct facies and phenotypic variability. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q24.2 Cellular Component: extracellular matrix; integral to membrane; plasma membrane Molecular Function:protein binding Biological Process: lens development in camera-type eye; regulation of protein heterodimerization activity; smoothened signaling pathway; satellite cell differentiation; cell fate specification; positive regulation of skeletal muscle development; anterior/posterior pattern formation; positive regulation of small GTPase mediated signal transduction; muscle cell differentiation; embryonic body morphogenesis; positive regulation of MAPKKK cascade; embryonic retina morphogenesis in camera-type eye; positive regulation of muscle cell differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of protein amino acid phosphorylation; cerebral cortex development; cell adhesion; positive regulation of neuron differentiation; myoblast fusion Disease: Holoprosencephaly 11 |
| NCBI Summary: | This gene encodes a cell surface receptor that is a member of the immunoglobulin superfamily. The encoded protein contains three fibronectin type III domains and five immunoglobulin-like C2-type domains. This protein is a member of a cell-surface receptor complex that mediates cell-cell interactions between muscle precursor cells and positively regulates myogenesis. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q4KMG0 |
| NCBI GenInfo Identifier: | 308153422 |
| NCBI Gene ID: | 50937 |
| NCBI Accession: | Q4KMG0.2 |
| UniProt Secondary Accession: | Q4KMG0,O14631, |
| UniProt Related Accession: | Q4KMG0 |
| Molecular Weight: | 136,527 Da |
| NCBI Full Name: | Cell adhesion molecule-related/down-regulated by oncogenes |
| NCBI Synonym Full Names: | cell adhesion associated, oncogene regulated |
| NCBI Official Symbol: | CDON |
| NCBI Official Synonym Symbols: | CDO; CDON1; HPE11; ORCAM |
| NCBI Protein Information: | cell adhesion molecule-related/down-regulated by oncogenes; Cdon homolog; surface glycoprotein, Ig superfamily member |
| UniProt Protein Name: | Cell adhesion molecule-related/down-regulated by oncogenes |
| Protein Family: | Cell adhesion molecule-related/down-regulated by oncogenes |
| UniProt Gene Name: | CDON |
| UniProt Entry Name: | CDON_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDON antibody (CAB15830) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |