Anti-CDK10 Antibody (CAB2690)
- SKU:
- CAB2690
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CDK10 Antibody |
| 抗体コード: | CAB2690 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human CDK10 (NP_001092003.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | 293T, HT-29 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human CDK10 (NP_001092003.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDKE KDGI PISS LREI TLLL RLRH PNIV ELKE VVVG NHLE SIFL VMGY CEQD LASL LENM PTPF SEAQ VKCI VLQV LRGL QYLH RNFI IHRD LKVS NLLM TDKG CVKT ADFG LARA YGVP VKPM TPKV VTLW YRAP ELLL GTTT QTTS IDMW AVGC ILAE LLAH RPLL PGTS EIHQ IDLI VQLL GTPS ENIW PGFS KLPL VGQY SLRK QPYN NLKH KFPW LSEA GLRL LHFL FMAT AGDC LESS YFKE KPLP CEPE LMPT FPHH RNKR AAPA TSEG QSKR CKP |
| 遺伝子ID: | 8558 |
| Uniprot: | Q15131 |
| セルラーロケーション: | |
| 計算された分子量: | 17kDa/21kDa/30kDa/31kDa/32kDa/41kDa |
| 観察された分子量: | 46kDa |
| 同義語: | CDK10, PISSLRE |
| バックグラウンド: | The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CDK10: a CMGC kinase of the CDK family. Plays a role in cellular proliferation. Its function is limited to cell cycle G2-M phase. At least three alternatively spliced isoforms have been reported, two of which contain multiple non-AUG translation initiation sites. |
| UniProt Protein Details: | Protein type:Protein kinase, Ser/Thr (non-receptor); Protein kinase, CMGC; Cell cycle regulation; Kinase, protein; EC 2.7.11.22; CMGC group; CDK family; CDK/CDK10 subfamily; CDK10 subfamily Chromosomal Location of Human Ortholog: 16q24 Molecular Function:protein binding; cyclin-dependent protein kinase activity; ATP binding Biological Process: negative regulation of cell proliferation; traversing start control point of mitotic cell cycle; positive regulation of MAPKKK cascade; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene belongs to the CDK subfamily of the Ser/Thr protein kinase family. The CDK subfamily members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and are known to be essential for cell cycle progression. This kinase has been shown to play a role in cellular proliferation and its function is limited to cell cycle G2-M phase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009] |
| UniProt Code: | Q15131 |
| NCBI GenInfo Identifier: | 6226784 |
| NCBI Gene ID: | 8558 |
| NCBI Accession: | Q15131.1 |
| UniProt Secondary Accession: | Q15131,Q0VGZ7, Q15130, Q6PJC0, A8K370, A8K8I6, A8MXU6 B3KQJ3, B7Z420, D3DX82, D3DX83, |
| UniProt Related Accession: | Q15131 |
| Molecular Weight: | 272 |
| NCBI Full Name: | Cyclin-dependent kinase 10 |
| NCBI Synonym Full Names: | cyclin-dependent kinase 10 |
| NCBI Official Symbol: | CDK10 |
| NCBI Official Synonym Symbols: | PISSLRE |
| NCBI Protein Information: | cyclin-dependent kinase 10; CDC2-related protein kinase; cell division protein kinase 10; cyclin-dependent kinase (CDC2-like) 10; cyclin-dependent kinase related protein; serine/threonine protein kinase PISSLRE; serine/threonine-protein kinase PISSLRE |
| UniProt Protein Name: | Cyclin-dependent kinase 10 |
| UniProt Synonym Protein Names: | Cell division protein kinase 10; Serine/threonine-protein kinase PISSLRE |
| Protein Family: | Cyclin-dependent kinase |
| UniProt Gene Name: | CDK10 |
| UniProt Entry Name: | CDK10_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDK10 antibody (CAB2690) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse brain using CDK10 antibody (CAB2690) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using CDK10 antibody (CAB2690) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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