| バックグラウンド: | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. |
| UniProt Protein Function: | CDH16: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 16q22.1 Biological Process: cell adhesion |
| NCBI Summary: | This gene is a member of the cadherin superfamily, genes encoding calcium-dependent, membrane-associated glycoproteins. Mapped to a previously identified cluster of cadherin genes on chromosome 16q22.1, the gene localizes with superfamily members CDH1, CDH3, CDH5, CDH8 and CDH11. The protein consists of an extracellular domain containing 6 cadherin domains, a transmembrane region and a truncated cytoplasmic domain but lacks the prosequence and tripeptide HAV adhesion recognition sequence typical of most classical cadherins. Expression is exclusively in kidney, where the protein functions as the principal mediator of homotypic cellular recognition, playing a role in the morphogenic direction of tissue development. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011] |
| UniProt Code: | O75309 |
| NCBI GenInfo Identifier: | 13431340 |
| NCBI Gene ID: | 1014 |
| NCBI Accession: | O75309.1 |
| UniProt Secondary Accession: | O75309,Q6UW93, B4DPA8, H3BPD3, |
| UniProt Related Accession: | O75309 |
| Molecular Weight: | 85,774 Da |
| NCBI Full Name: | Cadherin-16 |
| NCBI Synonym Full Names: | cadherin 16 |
| NCBI Official Symbol: | CDH16 |
| NCBI Protein Information: | cadherin-16 |
| UniProt Protein Name: | Cadherin-16 |
| UniProt Synonym Protein Names: | Kidney-specific cadherin; Ksp-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH16 |
| UniProt Entry Name: | CAD16_HUMAN |
