| バックグラウンド: | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. |
| UniProt Protein Function: | CDH10: Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 5p14.2 Cellular Component: plasma membrane |
| NCBI Summary: | This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. The extracellular domain consists of 5 subdomains, each containing a cadherin motif, and appears to determine the specificity of the protein's homophilic cell adhesion activity. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin is predominantly expressed in brain and is putatively involved in synaptic adhesions, axon outgrowth and guidance. Mutations in this gene may be associated with lung squamous cell carcinoma and colorectal cancer in human patients. [provided by RefSeq, Nov 2015] |
| UniProt Code: | Q9Y6N8 |
| NCBI GenInfo Identifier: | 116241276 |
| NCBI Gene ID: | 1008 |
| NCBI Accession: | Q9Y6N8.2 |
| UniProt Secondary Accession: | Q9Y6N8,Q9ULB3, |
| UniProt Related Accession: | Q9Y6N8 |
| Molecular Weight: | 88,451 Da |
| NCBI Full Name: | Cadherin-10 |
| NCBI Synonym Full Names: | cadherin 10 |
| NCBI Official Symbol: | CDH10 |
| NCBI Protein Information: | cadherin-10 |
| UniProt Protein Name: | Cadherin-10 |
| UniProt Synonym Protein Names: | T2-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH10 |
| UniProt Entry Name: | CAD10_HUMAN |
