| UniProt Protein Function: | CDCP1: a transmembrane protein containing three extracellular CUB domains involved in cell adhesion and cell matrix association. May play a role in the regulation of anchorage versus migration or proliferation versus differentiation depending upon its phosphorylation status. Interacts with N- and P-cadherin, syndecans 1 and 4, the serine protease ST14, SRC and PKCG. Highly expressed in mitotic cells with low expression during interphase. Detected at highest levels in skeletal muscle and colon with lower levels in kidney, small intestine, placenta and lung. Up-regulated in a number of human tumor cell lines, as well as in colorectal cancer, breast carcinoma and lung cancer. Its expression level is correlated with the metastatic ability of carcinoma cells. May be a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets. Belongs to the tetraspanin web involved in tumor progression and metastasis. Also expressed in cells with phenotypes reminiscent of mesenchymal stem cells and neural stem cells. Three alternatively spliced human isoforms have been reported. Isoform 1 is a single-pass membrane protein that may also be shed, giving rise to a soluble peptide. Isoform 3 is secreted. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.31 Molecular Function:protein binding |
| NCBI Summary: | This gene encodes a transmembrane protein which contains three extracellular CUB domains and acts as a substrate for Src family kinases. The protein plays a role in the tyrosine phosphorylation-dependent regulation of cellular events that are involved in tumor invasion and metastasis. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9H5V8 |
| NCBI GenInfo Identifier: | 317373455 |
| NCBI Gene ID: | 64866 |
| NCBI Accession: | Q9H5V8.3 |
| UniProt Secondary Accession: | Q9H5V8,Q49UB4, Q6NT71, Q6U9Y2, Q8WU91, Q96QU7, Q9H676 Q9H8C2, |
| UniProt Related Accession: | Q9H5V8 |
| Molecular Weight: | 37,818 Da |
| NCBI Full Name: | CUB domain-containing protein 1 |
| NCBI Synonym Full Names: | CUB domain containing protein 1 |
| NCBI Official Symbol: | CDCP1 |
| NCBI Official Synonym Symbols: | CD318; TRASK; SIMA135 |
| NCBI Protein Information: | CUB domain-containing protein 1 |
| UniProt Protein Name: | CUB domain-containing protein 1 |
| UniProt Synonym Protein Names: | Membrane glycoprotein gp140; Subtractive immunization M plus HEp3-associated 135 kDa protein; SIMA135; Transmembrane and associated with src kinases; CD_antigen: CD318 |
| Protein Family: | CUB domain-containing protein |
| UniProt Gene Name: | CDCP1 |
| UniProt Entry Name: | CDCP1_HUMAN |
