Anti-CDC73 Antibody (CAB0636)

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SKU:
CAB0636
Product type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
CDC73
Synonyms:
C1orf28
Synonyms:
FIHP
Synonyms:
HPTJT
Synonyms:
HRPT1
Synonyms:
HRPT2
Synonyms:
HYX
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Description

抗体名:CDC73 Rabbit pAb
抗体コード:CAB0636
サイズ:100uL
同義語:CDC73, C1orf28, FIHP, HPTJT, HRPT1, HRPT2, HYX
申し込み:WB
反応性:Human
宿主種:Rabbit
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 435-505 of human CDC73 (Q6P1J9).
申し込み:WB
推奨される希釈:WB 1:500 - 1:2000
反応性:Human
免疫原:Recombinant fusion protein containing a sequence corresponding to amino acids 435-505 of human CDC73 (Q6P1J9).
精製方法:Affinity purification
保管所:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
アイソタイプ:IgG
順序:Email for sequence
遺伝子ID:79577
Uniprot:Q6P1J9
セルラーロケーション:Nucleus
計算された分子量:60kDa
観察された分子量:Refer to figures
UniProt Protein Function:CDC73: Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of MLL1; it promotes leukemogenesis though association with MLL-rearranged oncoproteins, such as MLL-MLLT3/AF9 and MLL-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex and the E2 enzyme UBE2A or UBE2B to chromatin which mediate monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1); UB2A/B-mediated H2B ubiquitination is proposed to be coupled to transcription. PAF1C is involved in mRNA 3' end formation probably through association with cleavage and poly(A) factors. In case of infection by influenza A strain H3N2, PAF1C associates with viral NS1 protein, thereby regulating gene transcription. Connects PAF1C with the cleavage and polyadenylation specificity factor (CPSF) complex and the cleavage stimulation factor (CSTF) complex, and with Wnt signaling. Involved in polyadenylation of mRNA precursors. Component of the PAF1 complex, which consists of CDC73, PAF1, LEO1, CTR9, RTF1 and WDR61. Interacts with POLR2A, CPSF1, CPSF4, CSTF2, MLL and CTNNB1. Interacts with a Set1-like complex that has histone methyltransferase activity and methylates histone H3. Found in a complex with BCL9L or BCL9, CDC73, CTNNB1 and PYGO1 indicative for the participation in a nuclear Wnt signaling complex. Found in adrenal and parathyroid glands, kidney and heart. Belongs to the CDC73 family.
UniProt Protein Details:

Protein type:Tumor suppressor; Cell cycle regulation

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: nucleoplasm; nucleus

Molecular Function:protein binding

Biological Process: negative regulation of myeloid cell differentiation; Wnt receptor signaling pathway; endodermal cell fate commitment; transcription, DNA-dependent; protein destabilization; stem cell maintenance; histone H2B ubiquitination; positive regulation of mRNA 3'-end processing; mRNA polyadenylation; negative regulation of transcription from RNA polymerase II promoter; cell cycle; histone monoubiquitination; negative regulation of cell proliferation; negative regulation of fibroblast proliferation; positive regulation of RNA elongation from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; positive regulation of Wnt receptor signaling pathway; negative regulation of epithelial cell proliferation

Disease: Parathyroid Carcinoma

NCBI Summary:This gene encodes a tumor suppressor that is involved in transcriptional and post-transcriptional control pathways. The protein is a component of the the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A and with a histone methyltransferase complex. This protein appears to facilitate the association of 3' mRNA processing factors with actively-transcribed chromatin. Mutations in this gene have been linked to hyperparathyroidism-jaw tumor syndrome, familial isolated hyperparathyroidism, and parathyroid carcinoma. [provided by RefSeq, Jul 2009]
UniProt Code:Q6P1J9
NCBI GenInfo Identifier:74749063
NCBI Gene ID:79577
NCBI Accession:Q6P1J9.1
UniProt Related Accession:Q6P1J9
Molecular Weight:Predicted Molecular Mass: 38kDaAccurate Molecular Mass: 38kDa
NCBI Full Name:Parafibromin
NCBI Synonym Full Names:cell division cycle 73
NCBI Official Symbol:CDC73  
NCBI Official Synonym Symbols:HYX; FIHP; HPTJT; HRPT1; HRPT2; C1orf28  
NCBI Protein Information:parafibromin
UniProt Protein Name:Parafibromin
UniProt Synonym Protein Names:Cell division cycle protein 73 homolog; Hyperparathyroidism 2 protein
Protein Family:Cell division cycle protein
UniProt Gene Name:CDC73  
UniProt Entry Name:CDC73_HUMAN
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