Anti-CDC42BPA Antibody (CAB18396)
- SKU:
- CAB18396
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
Frequently bought together:
Description
| 抗体名: | Anti-CDC42BPA Antibody |
| 抗体コード: | CAB18396 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human CDC42BPA. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant protein of human CDC42BPA. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 8476 |
| Uniprot: | Q5VT25 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | MRCK, MRCKA, PK428, CDC42BPA |
| バックグラウンド: |
| UniProt Protein Function: | MRCKA: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration. Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2. In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Phosphorylates: PPP1R12A, LIMK1 and LIMK2. May play a role in TFRC-mediated iron uptake. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Protein kinase, AGC; Kinase, protein; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); AGC group; DMPK family; GEK subfamily Chromosomal Location of Human Ortholog: 1q42.11 Cellular Component: cytoplasm; leading edge; actomyosin; intercellular junction Molecular Function:identical protein binding; protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding Biological Process: cell migration; regulation of catalytic activity; actomyosin structure organization and biogenesis; actin cytoskeleton reorganization; microtubule cytoskeleton organization and biogenesis; nuclear migration; protein amino acid phosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2018] |
| UniProt Code: | Q5VT25 |
| NCBI GenInfo Identifier: | 30089962 |
| NCBI Gene ID: | 8476 |
| NCBI Accession: | NP_003598.2 |
| UniProt Related Accession: | Q5VT25 |
| Molecular Weight: | |
| NCBI Full Name: | serine/threonine-protein kinase MRCK alpha isoform B |
| NCBI Synonym Full Names: | CDC42 binding protein kinase alpha |
| NCBI Official Symbol: | CDC42BPA |
| NCBI Official Synonym Symbols: | MRCK; MRCKA; PK428 |
| NCBI Protein Information: | serine/threonine-protein kinase MRCK alpha |
| UniProt Protein Name: | Serine/threonine-protein kinase MRCK alpha |
| UniProt Synonym Protein Names: | CDC42-binding protein kinase alpha; DMPK-like alpha; Myotonic dystrophy kinase-related CDC42-binding kinase alpha |
| UniProt Gene Name: | CDC42BPA |
| UniProt Entry Name: | MRCKA_HUMAN |