Anti-CDAN1 Antibody (CAB17833)
- SKU:
- CAB17833
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-CDAN1 Antibody |
| 抗体コード: | CAB17833 |
| 抗体サイズ: | 20uL, 50 uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide of Human CDAN1. |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: |
| 免疫原: | A synthetic peptide of Human CDAN1. |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 146059 |
| Uniprot: | Q8IWY9 |
| セルラーロケーション: | |
| 計算された分子量: | |
| 観察された分子量: | Refer to figures |
| 同義語: | CDA1, CDAI, CDAN1A, DLT, PRO1295, CDAN1 |
| バックグラウンド: | This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009] |
| UniProt Protein Function: | CDAN1: Might be involved in nuclear membrane integrity. Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1). An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 15q15.2 Cellular Component: cytoplasm; plasma membrane; integral to membrane; endomembrane system; nucleus Molecular Function:protein binding Biological Process: protein localization; establishment and/or maintenance of chromatin architecture; negative regulation of DNA replication; chromatin assembly Disease: Anemia, Congenital Dyserythropoietic, Type Ia |
| NCBI Summary: | This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. [provided by RefSeq, Jul 2009] |
| UniProt Code: | Q8IWY9 |
| NCBI GenInfo Identifier: | 57222570 |
| NCBI Gene ID: | 146059 |
| NCBI Accession: | NP_612486.2 |
| UniProt Secondary Accession: | Q8IWY9,Q6NYD0, Q7Z7L5, Q969N3, |
| UniProt Related Accession: | Q8IWY9 |
| Molecular Weight: | Calculated MW: 134kDaObserved MW: 130kDa |
| NCBI Full Name: | codanin-1 |
| NCBI Synonym Full Names: | codanin 1 |
| NCBI Official Symbol: | CDAN1 |
| NCBI Official Synonym Symbols: | DLT; CDA1; CDAI; CDAN1A; PRO1295 |
| NCBI Protein Information: | codanin-1; congenital dyserythropoietic anemia, type I; discs lost homolog |
| UniProt Protein Name: | Codanin-1 |
| Protein Family: | Codanin |
| UniProt Gene Name: | CDAN1 |
| UniProt Entry Name: | CDAN1_HUMAN |