Anti-CD82 Antibody (CAB9264)
- SKU:
- CAB9264
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CD82 Antibody |
| 抗体コード: | CAB9264 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human CD82 |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | HT-29, Jurkat, Raji |
| 免疫原: | A synthesized peptide derived from human CD82 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 3732 |
| Uniprot: | P27701 |
| セルラーロケーション: | |
| 計算された分子量: | 30-60kDa |
| 観察された分子量: | 45-50KDa |
| 同義語: | 4F9, C33, GR15, IA4, KAI1, R2, SAR2, ST6, TSPAN27 |
| バックグラウンド: | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CD82: a widespread transmembrane protein of the tetraspanin family. A metastasis-suppressor whose decreased expression may be involved in malignant progression. Suppresses tumor metastasis of many cancers including cancers of the prostate, bladder, colon, cervix, liver, and lung (NSCLC). It is a target of estrogen receptor-mediated gene repression and is downregulated in primary human breast cancer. May be a prognostic marker for lung cancer and tumor metastatic potential. Interacts with cell surface proteins including integrins, cadherins, CD4, CD8, IGSF8. Modulates EGFR signaling. May suppress invasion by inhibiting integrin-dependent crosstalk with c-Met receptor and Src kinases. Its regulation of c-Met signaling apparently affects cancer cell migration. |
| UniProt Protein Details: | Protein type:Cell surface; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 11p11.2 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding Disease: Prostate Cancer |
| NCBI Summary: | This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27701 |
| NCBI GenInfo Identifier: | 4504813 |
| NCBI Gene ID: | 3732 |
| NCBI Accession: | NP_002222 |
| UniProt Secondary Accession: | P27701,Q7Z2D4, Q7Z5N2, D3DQN6, E9PC70, |
| UniProt Related Accession: | P27701 |
| Molecular Weight: | 26,818 Da |
| NCBI Full Name: | CD82 antigen isoform 1 |
| NCBI Synonym Full Names: | CD82 molecule |
| NCBI Official Symbol: | CD82 |
| NCBI Official Synonym Symbols: | R2; 4F9; C33; IA4; ST6; GR15; KAI1; SAR2; TSPAN27 |
| NCBI Protein Information: | CD82 antigen; tspan-27; C33 antigen; tetraspanin-27; inducible membrane protein R2; metastasis suppressor Kangai-1; kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)) |
| UniProt Protein Name: | CD82 antigen |
| UniProt Synonym Protein Names: | C33 antigen; IA4; Inducible membrane protein R2; Metastasis suppressor Kangai-1; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; Tspan-27; CD_antigen: CD82 |
| Protein Family: | CD82 antigen |
| UniProt Gene Name: | CD82 |
| UniProt Entry Name: | CD82_HUMAN |
 | Western blot - CD82 Rabbit mAb (CAB9264) |
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