Anti-CD320 antigen Antibody (CAB8627)
- SKU:
- CAB8627
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CD320 antigen Antibody |
抗体コード: | CAB8627 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1). |
申し込み: | WB |
推奨希釈: | WB 1:200 - 1:2000 |
反応性: | Human, Mouse |
ポジティブサンプル: | Mouse testis |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 36-229 of human CD320 (NP_057663.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | SPLS TPTS AQAA GPSS GSCP PTKF QCRT SGLC VPLT WRCD RDLD CSDG SDEE ECRI EPCT QKGQ CPPP PGLP CPCT GVSD CSGG TDKK LRNC SRLA CLAG ELRC TLSD DCIP LTWR CDGH PDCP DSSD ELGC GTNE ILPE GDAT TMGP PVTL ESVT SLRN ATTM GPPV TLES VPSV GNAT SSSA GDQS GSPT AY |
遺伝子ID: | 51293 |
Uniprot: | Q9NPF0 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 24kDa/28kDa |
観察された分子量: | 30kDa |
同義語: | CD320, 8D6, 8D6A, TCBLR |
バックグラウンド: | This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | Receptor for transcobalamin saturated with cobalamin (TCbl) (PubMed:18779389). Plays an important role in cobalamin uptake (PubMed:18779389, PubMed:20524213). Plasma membrane protein that is expressed on follicular dendritic cells (FDC) and mediates interaction with germinal center B cells (PubMed:10727470). Functions as costimulator to promote B cell responses to antigenic stimuli; promotes B cell differentiation and proliferation (PubMed:10727470, PubMed:11418631). Germinal center-B (GC-B) cells differentiate into memory B-cells and plasma cells (PC) through interaction with T-cells and follicular dendritic cells (FDC) (PubMed:11418631). CD320 augments the proliferation of PC precursors generated by IL-10 (PubMed:11418631). |
NCBI Summary: | This gene encodes the transcobalamin receptor that is expressed at the cell surface. It mediates the cellular uptake of transcobalamin bound cobalamin (vitamin B12), and is involved in B-cell proliferation and immunoglobulin secretion. Mutations in this gene are associated with methylmalonic aciduria. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011] |
UniProt Code: | Q9NPF0 |
NCBI GenInfo Identifier: | 74734303 |
NCBI Gene ID: | 51293 |
NCBI Accession: | Q9NPF0.1 |
UniProt Secondary Accession: | Q9NPF0,Q53HF7, B2RDS5, D6W668, F5H6D3, |
UniProt Related Accession: | Q9NPF0 |
Molecular Weight: | 24,371 Da |
NCBI Full Name: | CD320 antigen |
NCBI Synonym Full Names: | CD320 molecule |
NCBI Official Symbol: | CD320 |
NCBI Official Synonym Symbols: | 8D6; 8D6A; TCBLR |
NCBI Protein Information: | CD320 antigen |
UniProt Protein Name: | CD320 antigen |
UniProt Synonym Protein Names: | 8D6 antigen |
Protein Family: | CD320 antigen |
UniProt Gene Name: | CD320 |
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