Anti-CD2BP2 Antibody (CAB15777)
- SKU:
- CAB15777
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
| 抗体名: | Anti-CD2BP2 Antibody |
| 抗体コード: | CAB15777 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CD2BP2 (NP_006101.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | A-549, 293T, LO2 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-341 of human CD2BP2 (NP_006101.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MPKR KVTF QGVG DEED EDEI IVPK KKLV DPVA GSGG PGSR FKGK HSLD SDEE EDDD DGGS SKYD ILAS EDVE GQEA ATLP SEGG VRIT PFNL QEEM EEGH FDAD GNYF LNRD AQIR DSWL DNID WVKI RERP PGQR QASD SEEE DSLG QTSM SAQA LLEG LLEL LLPR ETVA GALR RLGA RGGG KGRK GPGQ PSSP QRLD RLSG LADQ MVAR GNLG VYQE TRER LAMR LKGL GCQT LGPH NPTP PPSL DMFA EELA EEEL ETPT PTQR GEAE SRGD GLVD VMWE YKWE NTGD AELY GPFT SAQM QTWV SEGY FPDG VYCR KLDP PGGQ FYNS KRID FDLY T |
| 遺伝子ID: | 10421 |
| Uniprot: | O95400 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 54kDa |
| 同義語: | CD2BP2, FWP010, LIN1, PPP1R59, Snu40, U5-52K |
| バックグラウンド: | This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. |
| UniProt Protein Function: | CD2BP2: Binds the cytoplasmic domain of CD2 through the GYF domain. |
| UniProt Protein Details: | Protein type:RNA processing; Adaptor/scaffold; Spliceosome Chromosomal Location of Human Ortholog: 16p11.2 Cellular Component: cytoplasm; nuclear speck; nucleoplasm; nucleus; snRNP U5; U4/U6 x U5 tri-snRNP complex Molecular Function:protein binding; ribonucleoprotein binding Biological Process: nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | This gene encodes a bi-functional protein. In the cytoplasm, the encoded protein binds the cytoplasmic tail of human surface antigen CD2 via its C-terminal GYF domain, and regulate CD2-triggered T lymphocyte activation. In the nucleus, this protein is a component of the U5 small nuclear ribonucleoprotein complex and is involved in RNA splicing. A pseudogene has been identified on chromosome 7. Alternative splicing results in multiple transcript variants but their biological validity has not been determined. [provided by RefSeq, Nov 2008] |
| UniProt Code: | O95400 |
| NCBI GenInfo Identifier: | 31339956 |
| NCBI Gene ID: | 10421 |
| NCBI Accession: | O95400.1 |
| UniProt Secondary Accession: | O95400,Q9ULP2, B2RDX2, |
| UniProt Related Accession: | O95400 |
| Molecular Weight: | 37,646 Da |
| NCBI Full Name: | CD2 antigen cytoplasmic tail-binding protein 2 |
| NCBI Synonym Full Names: | CD2 cytoplasmic tail binding protein 2 |
| NCBI Official Symbol: | CD2BP2 |
| NCBI Official Synonym Symbols: | LIN1; Snu40; FWP010; U5-52K; PPP1R59 |
| NCBI Protein Information: | CD2 antigen cytoplasmic tail-binding protein 2 |
| UniProt Protein Name: | CD2 antigen cytoplasmic tail-binding protein 2 |
| UniProt Synonym Protein Names: | U5 snRNP 52K protein; U5-52K |
| Protein Family: | CD2 antigen cytoplasmic tail-binding protein |
| UniProt Gene Name: | CD2BP2 |
| UniProt Entry Name: | CD2B2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CD2BP2 antibody (CAB15777) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
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