Anti-CD22 Antibody (CAB5790)
- SKU:
- CAB5790
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CD22 Antibody |
| 抗体コード: | CAB5790 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 708-847 of human CD22 (NP_001762.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Raji |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 708-847 of human CD22 (NP_001762.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | LQRR WKRT QSQQ GLQE NSSG QSFF VRNK KVRR APLS EGPH SLGC YNPM MEDG ISYT TLRF PEMN IPRT GDAE SSEM QRPP PDCD DTVT YSAL HKRQ VGDY ENVI PDFP EDEG IHYS ELIQ FGVG ERPQ AQEN VDYV ILKH |
| 遺伝子ID: | 933 |
| Uniprot: | P20273 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 75kDa/84kDa/85kDa/95kDa |
| 観察された分子量: | 135kDa |
| 同義語: | CD22, SIGLEC-2, SIGLEC2 |
| バックグラウンド: |
| UniProt Protein Function: | CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 19q13.1 Cellular Component: integral to plasma membrane; external side of plasma membrane Molecular Function:protein binding; carbohydrate binding Biological Process: cell adhesion |
| UniProt Code: | P20273 |
| NCBI GenInfo Identifier: | 6166019 |
| NCBI Gene ID: | 933 |
| NCBI Accession: | P20273.2 |
| UniProt Secondary Accession: | P20273,O95699, O95701, O95702, O95703, Q01665, Q32M46 Q92872, Q92873, Q9UQA6, F5GYU4, F5H7U3, |
| UniProt Related Accession: | P20273 |
| Molecular Weight: | 75,354 Da |
| NCBI Full Name: | B-cell receptor CD22 |
| NCBI Synonym Full Names: | CD22 molecule |
| NCBI Official Symbol: | CD22 |
| NCBI Official Synonym Symbols: | SIGLEC2; SIGLEC-2 |
| NCBI Protein Information: | B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2 |
| UniProt Protein Name: | B-cell receptor CD22 |
| UniProt Synonym Protein Names: | B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14; CD_antigen: CD22 |
| Protein Family: | CD226 antigen |
| UniProt Gene Name: | CD22 |
| UniProt Entry Name: | CD22_HUMAN |
 | Western blot analysis of extracts of Raji cells, using CD22 Antibody (CAB5790) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). |
 | Immunofluorescence analysis of U2OS cells using CD22 antibody (CAB5790). Blue: DAPI for nuclear staining. |
View AllClose