Anti-CD2 Antibody (CAB5632)
- SKU:
- CAB5632
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-CD2 Antibody |
抗体コード: | CAB5632 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-351 of human CD2 (NP_001758.2). |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | BxPC-3, LO2, Mouse thymus, Rat liver |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 235-351 of human CD2 (NP_001758.2). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | TKRK KQRS RRND EELE TRAH RVAT EERG RKPH QIPA STPQ NPAT SQHP PPPP GHRS QAPS HRPP PPGH RVQH QPQK RPPA PSGT QVHQ QKGP PLPR PRVQ PKPP HGAA ENSL SPSS N |
遺伝子ID: | 914 |
Uniprot: | P06729 |
セルラーロケーション: | Membrane, Single-pass type I membrane protein |
計算された分子量: | 39kDa |
観察された分子量: | 60kDa |
同義語: | CD2, LFA-2, SRBC, T11 |
バックグラウンド: |
UniProt Protein Function: | CD2: CD2 interacts with lymphocyte function-associated antigen (LFA-3) and CD48/BCM1 to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T- cells, the cytoplasmic domain is implicated in the signaling function. |
UniProt Protein Details: | Protein type:Cell surface; Membrane protein, integral; Apoptosis Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: anchored to plasma membrane; cell surface; external side of plasma membrane; extracellular region; integral to plasma membrane; intercellular junction; internal side of plasma membrane; plasma membrane Molecular Function:protein binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: apoptosis; cell surface receptor linked signal transduction; cell-cell adhesion; heterotypic cell-cell adhesion; leukocyte migration; lipid raft polarization; natural killer cell activation; positive regulation of myeloid dendritic cell activation; positive regulation of tumor necrosis factor production; regulation of T cell differentiation; T cell activation |
NCBI Summary: | CD2 is a surface antigen of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells (summarized by Sewell et al., 1986 [PubMed 3490670]). It is one of the earliest T-cell markers, being present on more than 95% of thymocytes; it is also found on some natural killer cells but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it.[supplied by OMIM, Jul 2010] |
UniProt Code: | P06729 |
NCBI GenInfo Identifier: | 160370002 |
NCBI Gene ID: | 914 |
NCBI Accession: | P06729.2 |
UniProt Secondary Accession: | P06729,Q96TE5, |
UniProt Related Accession: | P06729 |
Molecular Weight: | 39,448 Da |
NCBI Full Name: | T-cell surface antigen CD2 |
NCBI Synonym Full Names: | CD2 molecule |
NCBI Official Symbol: | CD2 |
NCBI Official Synonym Symbols: | T11; SRBC; LFA-2 |
NCBI Protein Information: | T-cell surface antigen CD2 |
UniProt Protein Name: | T-cell surface antigen CD2 |
UniProt Synonym Protein Names: | Erythrocyte receptor; LFA-2; LFA-3 receptor; Rosette receptor; T-cell surface antigen T11/Leu-5; CD_antigen: CD2 |
Protein Family: | CD2 |
UniProt Gene Name: | CD2 |
UniProt Entry Name: | CD2_HUMAN |