Anti-CD1D Antibody (CAB13475)
- SKU:
- CAB13475
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CD1D Antibody |
| 抗体コード: | CAB13475 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-190 of human CD1D (NP_001757.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse liver |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-190 of human CD1D (NP_001757.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EVPQ RLFP LRCL QISS FANS SWTR TDGL AWLG ELQT HSWS NDSD TVRS LKPW SQGT FSDQ QWET LQHI FRVY RSSF TRDV KEFA KMLR LSYP LELQ VSAG CEVH PGNA SNNF FHVA FQGK DILS FQGT SWEP TQEA PLWV NLAI QVLN QDKW TRET VQWL LNGT CPQF VSG |
| 遺伝子ID: | 912 |
| Uniprot: | P15813 |
| セルラーロケーション: | Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
| 計算された分子量: | 37kDa |
| 観察された分子量: | 35kDa |
| 同義語: | CD1D, CD1A, R3, R3G1 |
| バックグラウンド: | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CD1D: Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T-cells. |
| UniProt Protein Details: | Protein type:Apoptosis; Membrane protein, integral; Lipid-binding; Cell surface Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cell surface; lysosomal membrane; integral to plasma membrane; cytoplasm; endosome membrane Molecular Function:histone binding; beta-2-microglobulin binding; exogenous lipid antigen binding; lipid antigen binding; cell adhesion molecule binding; receptor activity; endogenous lipid antigen binding Biological Process: antigen processing and presentation, endogenous lipid antigen via MHC class Ib; heterotypic cell-cell adhesion; detection of bacterium; viral reproduction; positive regulation of innate immune response; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; T cell selection; innate immune response; positive regulation of T cell proliferation |
| NCBI Summary: | This gene encodes a divergent member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016] |
| UniProt Code: | P15813 |
| NCBI GenInfo Identifier: | 115964 |
| NCBI Gene ID: | 912 |
| NCBI Accession: | P15813.1 |
| UniProt Related Accession: | P15813 |
| Molecular Weight: | ~ 37kDa |
| NCBI Full Name: | Antigen-presenting glycoprotein CD1d |
| NCBI Synonym Full Names: | CD1d molecule |
| NCBI Official Symbol: | CD1D |
| NCBI Official Synonym Symbols: | R3; CD1A; R3G1 |
| NCBI Protein Information: | antigen-presenting glycoprotein CD1d |
| UniProt Protein Name: | Antigen-presenting glycoprotein CD1d |
| UniProt Synonym Protein Names: | R3G1; CD_antigen: CD1d |
| Protein Family: | Antigen-presenting glycoprotein |
| UniProt Gene Name: | CD1D |
| UniProt Entry Name: | CD1D_HUMAN |
 | Western blot analysis of extracts of mouse liver, using CD1D antibody (CAB13475) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunohistochemistry of paraffin-embedded human kidney cancer using CD1D antibody (CAB13475) at dilution of 1:200 (40x lens). |
 | Immunofluorescence analysis of HeLa cells using CD1D antibody (CAB13475). Blue: DAPI for nuclear staining. |
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