Anti-CD1B Antibody (CAB6551)
- SKU:
- CAB6551
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CD1B Antibody |
| 抗体コード: | CAB6551 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-303 of human CD1B (NP_001755.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | NCI-H125 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-303 of human CD1B (NP_001755.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | SEHA FQGP TSFH VIQT SSFT NSTW AQTQ GSGW LDDL QIHG WDSD SGTA IFLK PWSK GNFS DKEV AELE EIFR VYIF GFAR EVQD FAGD FQMK YPFE IQGI AGCE LHSG GAIV SFLR GALG GLDF LSVK NASC VPSP EGGS RAQK FCAL IIQY QGIM ETVR ILLY ETCP RYLL GVLN AGKA DLQR QVKP EAWL SSGP SPGP GRLQ LVCH VSGF YPKP VWVM WMRG EQEQ QGTQ LGDI LPNA NWTW YLRA TLDV ADGE AAGL SCRV KHSS LEGQ DIIL YWRN PTSI GS |
| 遺伝子ID: | 910 |
| Uniprot: | P29016 |
| セルラーロケーション: | Cell membrane, Endosome membrane, Lysosome membrane, Single-pass type I membrane protein |
| 計算された分子量: | 30kDa/36kDa |
| 観察された分子量: | 47kDa |
| 同義語: | CD1B, CD1, CD1A, R1 |
| バックグラウンド: | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. |
| UniProt Protein Function: | CD1B: Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cell surface; plasma membrane Molecular Function:beta-2-microglobulin binding; endogenous lipid antigen binding; exogenous lipid antigen binding; protein binding Biological Process: antigen processing and presentation, exogenous lipid antigen via MHC class Ib; regulation of immune response |
| NCBI Summary: | This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P29016 |
| NCBI GenInfo Identifier: | 115962 |
| NCBI Gene ID: | 910 |
| NCBI Accession: | P29016.1 |
| UniProt Secondary Accession: | P29016,Q5TDK9, Q5TDL0, Q9UMM2, |
| UniProt Related Accession: | P29016 |
| Molecular Weight: | 30,740 Da |
| NCBI Full Name: | T-cell surface glycoprotein CD1b |
| NCBI Synonym Full Names: | CD1b molecule |
| NCBI Official Symbol: | CD1B |
| NCBI Official Synonym Symbols: | R1; CD1; CD1A |
| NCBI Protein Information: | T-cell surface glycoprotein CD1b |
| UniProt Protein Name: | T-cell surface glycoprotein CD1b |
| UniProt Synonym Protein Names: | CD_antigen: CD1b |
| Protein Family: | T-cell surface glycoprotein |
| UniProt Gene Name: | CD1B |
| UniProt Entry Name: | CD1B_HUMAN |
 | Western blot analysis of extracts of NCI-H125 cells, using CD1B Antibody (CAB6551) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |