Anti-CD180 Antibody (CAB10226)
- SKU:
- CAB10226
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CD180 Antibody |
| 抗体コード: | CAB10226 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:1000 - 1:2000 |
| 反応性: | Human |
| ポジティブサンプル: | Raji, A-549, LO2, THP-1 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-220 of human CD180 (NP_005573.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | WDQM CIEK EANK TYNC ENLG LSEI PDTL PNTT EFLE FSFN FLPT IHNR TFSR LMNL TFLD LTRC QINW IHED TFQS HHQL STLV LTGN PLIF MAET SLNG PKSL KHLF LIQT GISN LEFI PVHN LENL ESLY LGSN HISS IKFP KDFP ARNL KVLD FQNN AIHY ISRE DMRS LEQA INLS LNFN GNNV KGIE LGAF D |
| 遺伝子ID: | 4064 |
| Uniprot: | Q99467 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 74kDa |
| 観察された分子量: | 105kDa |
| 同義語: | CD180, LY64, Ly78, RP105 |
| バックグラウンド: | CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. |
| UniProt Protein Function: | CD180: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells. Belongs to the Toll-like receptor family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 5q12.3 Cellular Component: integral to plasma membrane Molecular Function:receptor activity Biological Process: inflammatory response; positive regulation of lipopolysaccharide-mediated signaling pathway; toll-like receptor signaling pathway |
| NCBI Summary: | CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q99467 |
| NCBI GenInfo Identifier: | 296434437 |
| NCBI Gene ID: | 4064 |
| NCBI Accession: | Q99467.2 |
| UniProt Secondary Accession: | Q99467,Q32MM5, B2R7Z7, |
| UniProt Related Accession: | Q99467 |
| Molecular Weight: | 74kDa |
| NCBI Full Name: | CD180 antigen |
| NCBI Synonym Full Names: | CD180 molecule |
| NCBI Official Symbol: | CD180 |
| NCBI Official Synonym Symbols: | LY64; Ly78; RP105 |
| NCBI Protein Information: | CD180 antigen |
| UniProt Protein Name: | CD180 antigen |
| UniProt Synonym Protein Names: | Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD_antigen: CD180 |
| Protein Family: | CD180 antigen |
| UniProt Gene Name: | CD180 |
 | Western blot analysis of extracts of various cell lines, using CD180 antibody (CAB10226) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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