Anti-CCR9 Antibody (CAB14848)
- SKU:
- CAB14848
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-CCR9 Antibody |
| 抗体コード: | CAB14848 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR9 (NP_112477.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse brain |
| 免疫原: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human CCR9 (NP_112477.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MTPT DFTS PIPN MADD YGSE STSS MEDY VNFN FTDF YCEK NNVR QFAS HFLP PLYW LVFI VGAL GNSL VILV YWYC TRVK TMTD MFLL NLAI ADLL FLVT |
| 遺伝子ID: | 10803 |
| Uniprot: | P51686 |
| セルラーロケーション: | Cell membrane, Multi-pass membrane protein |
| 計算された分子量: | 40kDa/42kDa |
| 観察された分子量: | 42kDa |
| 同義語: | CCR9, CC-CKR-9, CDw199, GPR-9-6, GPR28 |
| バックグラウンド: | The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CCR9: Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1 Chromosomal Location of Human Ortholog: 3p21.3 Cellular Component: cell surface; integral to plasma membrane; plasma membrane Molecular Function:C-C chemokine receptor activity; chemokine receptor activity Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; cellular defense response; immune response; chemotaxis |
| NCBI Summary: | The protein encoded by this gene is a member of the beta chemokine receptor family. It is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are key regulators of the thymocytes migration and maturation in normal and inflammation conditions. The specific ligand of this receptor is CCL25. It has been found that this gene is differentially expressed by T lymphocytes of small intestine and colon, suggested a role in the thymocytes recruitment and development that may permit functional specialization of immune responses in different segment of the gastrointestinal tract. This gene is mapped to the chemokine receptor gene cluster region. Two alternatively spliced transcript variants have been described. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P51686 |
| NCBI GenInfo Identifier: | 114152781 |
| NCBI Gene ID: | 10803 |
| NCBI Accession: | P51686.2 |
| UniProt Secondary Accession: | P51686,Q9WUT7, |
| UniProt Related Accession: | P51686 |
| Molecular Weight: | 40,713 Da |
| NCBI Full Name: | C-C chemokine receptor type 9 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 9 |
| NCBI Official Symbol: | CCR9 |
| NCBI Official Synonym Symbols: | GPR28; CDw199; GPR-9-6; CC-CKR-9 |
| NCBI Protein Information: | C-C chemokine receptor type 9; G protein-coupled receptor 28 |
| UniProt Protein Name: | C-C chemokine receptor type 9 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 28; GPR-9-6; CD_antigen: CDw199 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR9 |
| UniProt Entry Name: | CCR9_HUMAN |
 | Western blot analysis of extracts of Mouse brain, using CCR9 antibody (CAB14848) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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