Anti-CCR2 Antibody (RACO0571)
- SKU:
- RACO0571
- Product type:
- Recombinant Antibody
- Reactivity:
- Human
- Host Species:
- Human
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Conjugation:
- Unconjugated
Description
| 商品名: | CCR2 Antibody |
| Product SKU: | RACO0571 |
| サイズ: | 50ul |
| 宿主種: | Homo sapiens (Human) |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | A synthesized peptide derived from human CCR2/CKR2 |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | Affinity-chromatography |
| 抗体のクローン性: | Monoclonal |
| アイソタイプ: | Rabbit IgG |
| Conjugate: | Non-conjugated |
| バックグラウンド: | Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection. |
| シノニム: | C-C chemokine receptor type 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (Monocyte chemoattractant protein 1 receptor) (MCP-1-R) (CD antigen CD192), CCR2, CMKBR2 |
 | IHC image of RACO0571 diluted at 1:100 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB. |
| UniProt Protein Function: | CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: cell soma; integral to plasma membrane; perinuclear region of cytoplasm; dendrite; cytoplasm; integral to membrane; plasma membrane; perikaryon; cytosol Molecular Function:protein homodimerization activity; CCR2 chemokine receptor binding; C-C chemokine receptor activity; chemokine receptor activity Biological Process: positive regulation of T-helper 1 type immune response; viral reproduction; chemotaxis; elevation of cytosolic calcium ion concentration; response to wounding; dendritic cell chemotaxis; cellular homeostasis; inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; negative regulation of adenylate cyclase activity; JAK-STAT cascade; cellular calcium ion homeostasis; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; positive regulation of interferon-gamma production; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; innate immune response; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; positive regulation of T cell activation; negative regulation of eosinophil degranulation; positive regulation of inflammatory response |
| NCBI Summary: | This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P41597 |
| NCBI GenInfo Identifier: | 1168965 |
| NCBI Gene ID: | 729230 |
| NCBI Accession: | P41597.1 |
| UniProt Secondary Accession: | P41597,Q4VBL2, A0AVQ3, B2RMT0, |
| UniProt Related Accession: | P41597 |
| Molecular Weight: | 41,064 Da |
| NCBI Full Name: | C-C chemokine receptor type 2 |
| NCBI Synonym Full Names: | chemokine (C-C motif) receptor 2 |
| NCBI Official Symbol: | CCR2 |
| NCBI Official Synonym Symbols: | CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2 |
| NCBI Protein Information: | C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor |
| UniProt Protein Name: | C-C chemokine receptor type 2 |
| UniProt Synonym Protein Names: | Monocyte chemoattractant protein 1 receptor; MCP-1-R; CD_antigen: CD192 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR2 |
| UniProt Entry Name: | CCR2_HUMAN |