| UniProt Protein Function: | CCR1: Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 3p21 Cellular Component: external side of plasma membrane; integral to plasma membrane; plasma membrane Molecular Function:C-C chemokine binding; C-C chemokine receptor activity; chemokine receptor activity; phosphoinositide phospholipase C activity; protein binding Biological Process: calcium ion transport; cell adhesion; cell surface receptor linked signal transduction; cell-cell signaling; cellular calcium ion homeostasis; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; exocytosis; G-protein signaling, coupled to cyclic nucleotide second messenger; immune response; negative regulation of bone mineralization; positive regulation of calcium ion transport; positive regulation of cell migration; positive regulation of osteoclast differentiation; response to wounding |
| NCBI Summary: | This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The ligands of this receptor include macrophage inflammatory protein 1 alpha (MIP-1 alpha), regulated on activation normal T expressed and secreted protein (RANTES), monocyte chemoattractant protein 3 (MCP-3), and myeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. Knockout studies of the mouse homolog suggested the roles of this gene in host protection from inflammatory response, and susceptibility to virus and parasite. This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, are found to form a gene cluster on chromosome 3p. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32246 |
| NCBI GenInfo Identifier: | 416802 |
| NCBI Gene ID: | 1230 |
| NCBI Accession: | P32246.1 |
| UniProt Secondary Accession: | P32246,Q86VA9, |
| UniProt Related Accession: | P32246 |
| Molecular Weight: | 41,173 Da |
| NCBI Full Name: | C-C chemokine receptor type 1 |
| NCBI Synonym Full Names: | C-C motif chemokine receptor 1 |
| NCBI Official Symbol: | CCR1 |
| NCBI Official Synonym Symbols: | CKR1; CD191; CKR-1; HM145; CMKBR1; MIP1aR; SCYAR1 |
| NCBI Protein Information: | C-C chemokine receptor type 1 |
| UniProt Protein Name: | C-C chemokine receptor type 1 |
| UniProt Synonym Protein Names: | HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor; MIP-1alpha-R; RANTES-R; CD_antigen: CD191 |
| Protein Family: | C-C chemokine receptor |
| UniProt Gene Name: | CCR1 |
| UniProt Entry Name: | CCR1_HUMAN |
