Anti-CCNDBP1 Antibody (CAB13735)
- SKU:
- CAB13735
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Cycle
Frequently bought together:
Description
| 抗体名: | Anti-CCNDBP1 Antibody |
| 抗体コード: | CAB13735 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human CCNDBP1 (NP_036274.3). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, 22Rv1, A-549, BxPC-3, Mouse heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human CCNDBP1 (NP_036274.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MASA TAPA AAVP TLAS PLEQ LRHL AEEL RLLL PRVR VGEA QETT EEFN REMF WRRL NEAA VTVS REAT TLTI VFSQ LPLP SPQE TQKF CEQV HAAI KAFI AVYY LLPK DQGI TLRK LVRG ATLD IVDG MAQL MEVL SVTP TQSP ENND LISY NSVW VACQ QMPQ IPRD NKAA ALLM LTKN VDFV KDAH EEME QAVE ECDP YSGL LNDT EENN SDNH NHED DVLG FPSN QDLY WSED DQEL IIPC LALV RASK ACLK KIRM LVAE NGKK DQVA QLDD IVDI SDEI SPSV DDLA LSIY PPMC HLTV RINS AKLV SVLK KALE ITKA SHVT PQPE DSWI PLLI NAID HCMN RIKE LTQS ELEL |
| 遺伝子ID: | 23582 |
| Uniprot: | O95273 |
| セルラーロケーション: | Cytoplasm, Nucleus |
| 計算された分子量: | 22kDa/26kDa/34kDa/40kDa |
| 観察された分子量: | 42kDa |
| 同義語: | CCNDBP1, DIP1, GCIP, HHM |
| バックグラウンド: | This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. |
| UniProt Protein Function: | CCNDBP1: May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription. Belongs to the CCNDBP1 family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 15q14-q15 Cellular Component: nucleoplasm; nucleus Molecular Function:protein binding |
| NCBI Summary: | This gene was identified by the interaction of its gene product with Grap2, a leukocyte-specific adaptor protein important for immune cell signaling. The protein encoded by this gene was shown to interact with cyclin D. Transfection of this gene in cells was reported to reduce the phosphorylation of Rb gene product by cyclin D-dependent protein kinase, and inhibit E2F1-mediated transcription activity. This protein was also found to interact with helix-loop-helix protein E12 and is thought to be a negative regulator of liver-specific gene expression. Several alternatively spliced variants have been found for this gene. [provided by RefSeq, Apr 2009] |
| UniProt Code: | O95273 |
| NCBI GenInfo Identifier: | 172047302 |
| NCBI Gene ID: | 23582 |
| NCBI Accession: | O95273.2 |
| UniProt Secondary Accession: | O95273,Q6ZQN9, Q7Z519, Q8NBS7, Q8NBY2, Q9NS19, Q9NYH3 Q9UHX9, A8K3Q0, A8K3U2, |
| UniProt Related Accession: | O95273 |
| Molecular Weight: | 22,714 Da |
| NCBI Full Name: | Cyclin-D1-binding protein 1 |
| NCBI Synonym Full Names: | cyclin D1 binding protein 1 |
| NCBI Official Symbol: | CCNDBP1 |
| NCBI Official Synonym Symbols: | HHM; DIP1; GCIP |
| NCBI Protein Information: | cyclin-D1-binding protein 1 |
| UniProt Protein Name: | Cyclin-D1-binding protein 1 |
| UniProt Synonym Protein Names: | Grap2 and cyclin-D-interacting protein; Human homolog of Maid |
| Protein Family: | Cyclin-D1-binding protein |
| UniProt Gene Name: | CCNDBP1 |
| UniProt Entry Name: | CCDB1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCNDBP1 antibody (CAB13735) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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