Anti-CCL11 Antibody (CAB7569)
- SKU:
- CAB7569
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
抗体名: | Anti-CCL11 Antibody |
抗体コード: | CAB7569 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IHC IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human CCL11 (NP_002977.1). |
申し込み: | WB IHC IF |
推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-549, 293T, Mouse skeletal muscle |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human CCL11 (NP_002977.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MKVS AALL WLLL IAAA FSPQ GLAG PASV PTTC CFNL ANRK IPLQ RLES YRRI TSGK CPQK AVIF KTKL AKDI CADP KKKW VQDS MKYL DQKS PTPK P |
遺伝子ID: | 6356 |
Uniprot: | P51671 |
セルラーロケーション: | Secreted |
計算された分子量: | 10kDa |
観察された分子量: | 20kDa |
同義語: | CCL11, SCYA11, eotaxin |
バックグラウンド: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. |
UniProt Protein Function: | CCL11: In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3. Belongs to the intercrine beta (chemokine CC) family. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 17q12 Cellular Component: extracellular region; extracellular space; intracellular Molecular Function:CCR chemokine receptor binding; chemokine activity; protein binding Biological Process: actin filament organization; cell adhesion; cellular calcium ion homeostasis; chemotaxis; chronic inflammatory response; cytoskeleton organization and biogenesis; eosinophil chemotaxis; G-protein coupled receptor protein signaling pathway; inflammatory response; lymphocyte chemotaxis; mast cell chemotaxis; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of actin filament polymerization; positive regulation of angiogenesis; positive regulation of cell migration; positive regulation of endothelial cell proliferation; positive regulation of GTPase activity; positive regulation of inflammatory response; protein amino acid phosphorylation; regulation of cell shape; response to radiation; response to virus; signal transduction Disease: Asthma, Susceptibility To; Human Immunodeficiency Virus Type 1, Susceptibility To |
NCBI Summary: | This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity for eosinophils, but not mononuclear cells or neutrophils. This eosinophil-specific chemokine is thought to be involved in eosinophilic inflammatory diseases such as atopic dermatitis, allergic rhinitis, asthma and parasitic infections. [provided by RefSeq, Sep 2014] |
UniProt Code: | P51671 |
NCBI GenInfo Identifier: | 1706661 |
NCBI Gene ID: | 6356 |
NCBI Accession: | P51671.1 |
UniProt Secondary Accession: | P51671,P50877, Q92490, Q92491, |
UniProt Related Accession: | P51671 |
Molecular Weight: | 10,732 Da |
NCBI Full Name: | Eotaxin |
NCBI Synonym Full Names: | C-C motif chemokine ligand 11 |
NCBI Official Symbol: | CCL11 |
NCBI Official Synonym Symbols: | SCYA11 |
NCBI Protein Information: | eotaxin |
UniProt Protein Name: | Eotaxin |
UniProt Synonym Protein Names: | C-C motif chemokine 11; Eosinophil chemotactic protein; Small-inducible cytokine A11 |
Protein Family: | Eotaxin |
UniProt Gene Name: | CCL11 |
UniProt Entry Name: | CCL11_HUMAN |