| UniProt Protein Function: | CCKAR: Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family. |
| UniProt Protein Details: | Protein type:Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass; Membrane protein, integral Chromosomal Location of Human Ortholog: 4p15.2 Cellular Component: integral to plasma membrane; plasma membrane Biological Process: digestion; feeding behavior; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); regulation of hormone secretion |
| NCBI Summary: | This gene encodes a G-protein coupled receptor that binds non-sulfated members of the cholecystokinin (CCK) family of peptide hormones. This receptor is a major physiologic mediator of pancreatic enzyme secretion and smooth muscle contraction of the gallbladder and stomach. In the central and peripheral nervous system this receptor regulates satiety and the release of beta-endorphin and dopamine. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P32238 |
| NCBI GenInfo Identifier: | 416772 |
| NCBI Gene ID: | 886 |
| NCBI Accession: | P32238.1 |
| UniProt Secondary Accession: | P32238,B2R9Z5, |
| UniProt Related Accession: | P32238 |
| Molecular Weight: | 47,841 Da |
| NCBI Full Name: | Cholecystokinin receptor type A |
| NCBI Synonym Full Names: | cholecystokinin A receptor |
| NCBI Official Symbol: | CCKAR |
| NCBI Official Synonym Symbols: | CCK-A; CCK1R; CCKRA; CCK1-R |
| NCBI Protein Information: | cholecystokinin receptor type A |
| UniProt Protein Name: | Cholecystokinin receptor type A |
| UniProt Synonym Protein Names: | Cholecystokinin-1 receptor; CCK1-R |
| Protein Family: | Cholecystokinin receptor |
| UniProt Gene Name: | CCKAR |
| UniProt Entry Name: | CCKAR_HUMAN |
