Anti-CCDC6 Antibody (CAB19901)[KO Validated]
- SKU:
- CAB19901
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | Anti-CCDC6 Antibody [KO Validated] |
抗体コード: | CAB19901 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human CCDC6. |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | HeLa |
免疫原: | Recombinant protein of human CCDC6. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 8030 |
Uniprot: | Q16204 |
セルラーロケーション: | Cytoplasm, cytoskeleton |
計算された分子量: | 53kDa |
観察された分子量: | 68KDa |
同義語: | CCDC6, D10S170, H4, PTC, TPC, TST1 |
バックグラウンド: | This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma. |
UniProt Protein Function: | CCDC6: Defects in CCDC6 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving CCDC6 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q21) generates the RET/CCDC6 (PTC1) oncogene. |
UniProt Protein Details: | Protein type:Cytoskeletal; Oncoprotein; Apoptosis Chromosomal Location of Human Ortholog: 10q21 Cellular Component: cytoplasm Molecular Function:protein binding; structural constituent of cytoskeleton Disease: Thyroid Carcinoma, Papillary |
NCBI Summary: | This gene encodes a coiled-coil domain-containing protein. The encoded protein is ubiquitously expressed and may function as a tumor suppressor. A chromosomal rearrangement resulting in the expression of a fusion gene containing a portion of this gene and the intracellular kinase-encoding domain of the ret proto-oncogene is the cause of thyroid papillary carcinoma.[provided by RefSeq, Sep 2010] |
UniProt Code: | Q16204 |
NCBI GenInfo Identifier: | 292494979 |
NCBI Gene ID: | 8030 |
NCBI Accession: | Q16204.2 |
UniProt Secondary Accession: | Q16204,Q15250, Q6GSG7, |
UniProt Related Accession: | Q16204 |
Molecular Weight: | 53,291 Da |
NCBI Full Name: | Coiled-coil domain-containing protein 6 |
NCBI Synonym Full Names: | coiled-coil domain containing 6 |
NCBI Official Symbol: | CCDC6 |
NCBI Official Synonym Symbols: | H4; PTC; TPC; TST1; D10S170 |
NCBI Protein Information: | coiled-coil domain-containing protein 6 |
UniProt Protein Name: | Coiled-coil domain-containing protein 6 |
UniProt Synonym Protein Names: | Papillary thyroid carcinoma-encoded protein; Protein H4 |
Protein Family: | Coiled-coil domain-containing protein |
UniProt Gene Name: | CCDC6 |
UniProt Entry Name: | CCDC6_HUMAN |