Anti-CCBL1 Antibody (CAB6542)
- SKU:
- CAB6542
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CCBL1 Antibody |
| 抗体コード: | CAB6542 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCBL1 (NP_001116144.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:10 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Raji, HeLa, SW620, Mouse liver, Mouse kidney, Mouse heart, Rat kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human CCBL1 (NP_001116144.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MAKQ LQAR RLDG IDYN PWVE FVKL ASEH DVVN LGQG FPDF PPPD FAVE AFQH AVSG DFML NQYT KTFV IIIE PFFD CYEP MTMM AGGR PVFV SLKP GPIQ NGEL GSSS NWQL DPME LAGK FTSR TKAL VLNT PNNP LGKV FSRE ELEL VASL CQQH DVVC ITDE VYQW MVYD GHQH ISIA SLPG MWER TLTI GSAG KTFS ATGW KVGW VLGP DHIM KHLR TVHQ NSVF HCPT QSQA AVAE SFER EQLL FRQP SSYF VQFP QAMQ RCRD HM |
| 遺伝子ID: | 883 |
| Uniprot: | Q16773 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 27kDa/42kDa/47kDa |
| 観察された分子量: | 48kDa |
| 同義語: | KYAT1, CCBL1, GTK, KAT1, KATI |
| バックグラウンド: | This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. |
| UniProt Protein Function: | CCBL1: Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Metabolizes the cysteine conjugates of certain halogenated alkenes and alkanes to form reactive metabolites. Catalyzes the beta- elimination of S-conjugates and Se-conjugates of L- (seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond. Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.4.1.13; Lyase; EC 2.6.1.7; Transferase; EC 2.6.1.64 Chromosomal Location of Human Ortholog: 9q34.11 Cellular Component: cytoplasm; cytosol; nucleoplasm Molecular Function:glutamine-pyruvate transaminase activity; kynurenine-oxoglutarate transaminase activity; phenylalanine(histidine) transaminase activity; protein binding; protein homodimerization activity; transaminase activity Biological Process: amino acid biosynthetic process; amino acid derivative metabolic process; L-phenylalanine catabolic process; tryptophan catabolic process |
| NCBI Summary: | This gene encodes a cytosolic enzyme that is responsible for the metabolism of cysteine conjugates of certain halogenated alkenes and alkanes. This metabolism can form reactive metabolites leading to nephrotoxicity and neurotoxicity. Increased levels of this enzyme have been linked to schizophrenia. Multiple transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q16773 |
| NCBI GenInfo Identifier: | 46396284 |
| NCBI Gene ID: | 883 |
| NCBI Accession: | Q16773.1 |
| UniProt Secondary Accession: | Q16773,Q5T275, Q8N191, |
| UniProt Related Accession: | Q16773 |
| Molecular Weight: | 27,420 Da |
| NCBI Full Name: | Kynurenine--oxoglutarate transaminase 1 |
| NCBI Synonym Full Names: | kynurenine aminotransferase 1 |
| NCBI Official Symbol: | KYAT1 |
| NCBI Official Synonym Symbols: | GTK; KAT1; KATI; CCBL1 |
| NCBI Protein Information: | kynurenine--oxoglutarate transaminase 1 |
| UniProt Protein Name: | Kynurenine--oxoglutarate transaminase 1 |
| UniProt Synonym Protein Names: | Cysteine-S-conjugate beta-lyase (EC:4.4.1.13); Glutamine transaminase K; GTK; Glutamine--phenylpyruvate transaminase (EC:2.6.1.64); Kynurenine aminotransferase 1 |
| UniProt Gene Name: | KYAT1 |
| UniProt Entry Name: | KAT1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CCBL1 Antibody (CAB6542) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded mouse liver using CCBL1 antibody (CAB6542) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse heart using CCBL1 antibody (CAB6542) at dilution of 1:100 (40x lens). |
 | Immunofluorescence analysis of U2OS cells using CCBL1 antibody (CAB6542). Blue: DAPI for nuclear staining. |
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