Anti-CBX4 Antibody (CAB5109)
- SKU:
- CAB5109
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Frequently bought together:
Description
抗体名: | Anti-CBX4 Antibody |
抗体コード: | CAB5109 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | A synthesized peptide derived from human CBX4 |
申し込み: | WB |
推奨希釈: | WB 1:500 - 1:2000 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | MCF7, 22Rv1, K-562, Mouse brain, Rat brain |
免疫原: | A synthesized peptide derived from human CBX4 |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 8535 |
Uniprot: | O00257 |
セルラーロケーション: | |
計算された分子量: | 50kDa |
観察された分子量: | 60KDa |
同義語: | NBP16, PC2 |
バックグラウンド: |
UniProt Protein Function: | CBX4: E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; SUMO ligase; Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 17q25.3 Cellular Component: nucleoplasm; nucleus; PcG protein complex Molecular Function:enzyme binding; protein binding; SUMO binding; SUMO ligase activity; transcription corepressor activity Biological Process: negative regulation of apoptosis; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; protein sumoylation |
UniProt Code: | O00257 |
NCBI GenInfo Identifier: | 254763424 |
NCBI Gene ID: | 8535 |
NCBI Accession: | O00257.3 |
UniProt Secondary Accession: | O00257,Q6TPI8, Q96C04, B1PJR7, |
UniProt Related Accession: | O00257 |
Molecular Weight: | 31,987 Da |
NCBI Full Name: | E3 SUMO-protein ligase CBX4 |
NCBI Synonym Full Names: | chromobox 4 |
NCBI Official Symbol: | CBX4 |
NCBI Official Synonym Symbols: | PC2; NBP16 |
NCBI Protein Information: | E3 SUMO-protein ligase CBX4 |
UniProt Protein Name: | E3 SUMO-protein ligase CBX4 |
UniProt Synonym Protein Names: | Chromobox protein homolog 4; Polycomb 2 homolog; Pc2; hPc2 |
Protein Family: | E3 SUMO-protein ligase |
UniProt Gene Name: | CBX4 |
UniProt Entry Name: | CBX4_HUMAN |
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