Anti-CBR1 Antibody (CAB19263)
- SKU:
- CAB19263
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- CBR1
- Synonyms:
- CBR
- Synonyms:
- SDR21C1
- Synonyms:
- hCBR1
- Synonyms:
- carbonyl reductase 1
Frequently bought together:
Description
| 抗体名: | CBR1 Rabbit mAb |
| 抗体コード: | CAB19263 |
| サイズ: | 20uL, 50uL, 100uL |
| 同義語: | CBR1, CBR, SDR21C1, hCBR1, carbonyl reductase 1 |
| 申し込み: | WB, IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant protein of human CBR1. |
| 申し込み: | WB, IHC |
| 推奨される希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | 293T, A-549, U-251MG, Mouse testis, Mouse brain |
| 免疫原: | Recombinant protein of human CBR1. |
| 精製方法: | Affinity purification |
| 保管所: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 873 |
| Uniprot: | P16152 |
| セルラーロケーション: | Cytoplasm |
| 計算された分子量: | 30kDa |
| 観察された分子量: | 33KDa |
| UniProt Protein Function: | CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| UniProt Protein Details: | Protein type:EC 1.1.1.189; Lipid Metabolism - arachidonic acid; EC 1.1.1.197; Oxidoreductase; EC 1.1.1.184 Chromosomal Location of Human Ortholog: 21q22.13 Cellular Component: cytosol; vesicle Molecular Function:oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process |
| NCBI Summary: | The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013] |
| UniProt Code: | P16152 |
| NCBI GenInfo Identifier: | 118519 |
| NCBI Gene ID: | 873 |
| NCBI Accession: | P16152.3 |
| UniProt Secondary Accession: | P16152,Q3LHW8, B2RBZ7, B4DFK7, |
| UniProt Related Accession: | P16152 |
| Molecular Weight: | 277 |
| NCBI Full Name: | Carbonyl reductase |
| NCBI Synonym Full Names: | carbonyl reductase 1 |
| NCBI Official Symbol: | CBR1 |
| NCBI Official Synonym Symbols: | CBR; hCBR1; SDR21C1 |
| NCBI Protein Information: | carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1 |
| UniProt Protein Name: | Carbonyl reductase [NADPH] 1 |
| UniProt Synonym Protein Names: | 15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189) |
| Protein Family: | Carbonyl reductase |
| UniProt Gene Name: | CBR1 |
| UniProt Entry Name: | CBR1_HUMAN |