Anti-CBLL1 Antibody (CAB14932)
- SKU:
- CAB14932
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
| 抗体名: | Anti-CBLL1 Antibody |
| 抗体コード: | CAB14932 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | Mouse heart, Mouse brain, Mouse lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-240 of human CBLL1 (NP_079090.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MDHT DNEL QGTN SSGS LGGL DVRR RIPI KLIS KQAN KAKP APRT QRTI NRMP AKAP PGDE EGFD YNEE ERYD CKGG ELFA NQRR FPGH LFWD FQIN ILGE KDDT PVHF CDKC GLPI KIYG RMIP CKHV FCYD CAIL HEKK GDKM CPGC SDPV QRIE QCTR GSLF MCSI VQGC KRTY LSQR DLQA HINH RHMR AGKP VTRA SLEN VHPP IAPP PTEI PERF IMPP DKHH MSHI PPKQ HIMM |
| 遺伝子ID: | 79872 |
| Uniprot: | Q75N03 |
| セルラーロケーション: | Nucleus, Nucleus speckle, nucleoplasm |
| 計算された分子量: | 54kDa |
| 観察された分子量: | 60kDa |
| 同義語: | CBLL1, HAKAI, RNF188 |
| バックグラウンド: | This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. |
| UniProt Protein Function: | CBLL1: Promotes ubiquitination of tyrosine-phosphorylated CDH1, thus targeting CDH1 for endocytosis and degradation. |
| UniProt Protein Details: | Protein type:EC 6.3.2.19; Ligase; Motility/polarity/chemotaxis; EC 6.3.2.-; Cell adhesion; C2H2-type zinc finger protein; Ubiquitin conjugating system; Ubiquitin ligase Chromosomal Location of Human Ortholog: 7q22.3 Cellular Component: ubiquitin ligase complex Molecular Function:identical protein binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activity Biological Process: cell-cell adhesion; protein ubiquitination; positive regulation of endocytosis; negative regulation of cell adhesion; positive regulation of cell migration |
| NCBI Summary: | This gene encodes an E3 ubiquitin-ligase for the E-cadherin complex and mediates its ubiquitination, endocytosis, and degradation in the lysosomes. The encoded protein contains a RING-finger domain and is also thought to have a role in control of cell proliferation. A related pseudogene has been identified on chromosome X. Alternative splicing results in a non-coding transcript variant. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q75N03 |
| NCBI GenInfo Identifier: | 74762414 |
| NCBI Gene ID: | 79872 |
| NCBI Accession: | Q75N03.1 |
| UniProt Secondary Accession: | Q75N03,Q9JIY2, |
| UniProt Related Accession: | Q75N03 |
| Molecular Weight: | 491 |
| NCBI Full Name: | E3 ubiquitin-protein ligase Hakai |
| NCBI Synonym Full Names: | Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | CBLL1 |
| NCBI Official Synonym Symbols: | HAKAI; RNF188 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase Hakai; c-Cbl-like protein 1; RING finger protein 188; E-cadherin binding protein E7; Cbl proto-oncogene, E3 ubiquitin protein ligase-like 1; casitas B-lineage lymphoma-transforming sequence-like protein 1; Cas-Br-M (murine) eco |
| UniProt Protein Name: | E3 ubiquitin-protein ligase Hakai |
| UniProt Synonym Protein Names: | Casitas B-lineage lymphoma-transforming sequence-like protein 1; RING finger protein 188; c-Cbl-like protein 1 |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | CBLL1 |
| UniProt Entry Name: | HAKAI_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CBLL1 antibody (CAB14932) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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