| UniProt Protein Function: | Important for the overall degradation of proteins in lysosomes. |
| NCBI Summary: | The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012] |
| UniProt Code: | P07711 |
| NCBI GenInfo Identifier: | 115741 |
| NCBI Gene ID: | 1514 |
| NCBI Accession: | P07711.2 |
| UniProt Secondary Accession: | P07711,Q6IAV1, Q96QJ0, |
| UniProt Related Accession: | P07711 |
| Molecular Weight: | 38kDa |
| NCBI Full Name: | Cathepsin L1 |
| NCBI Synonym Full Names: | cathepsin L |
| NCBI Official Symbol: | CTSL |
| NCBI Official Synonym Symbols: | MEP; CATL; CTSL1 |
| NCBI Protein Information: | cathepsin L1 |
| UniProt Protein Name: | Cathepsin L1 |
| UniProt Synonym Protein Names: | Cathepsin L; Major excreted protein; MEP |
| UniProt Gene Name: | CTSL |
