Anti-CASQ2 Antibody (CAB16797)
- SKU:
- CAB16797
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CASQ2 Antibody |
| 抗体コード: | CAB16797 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse heart, Rat heart |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-399 of human CASQ2 (NP_001223.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | EEGL NFPT YDGK DRVV SLSE KNFK QVLK KYDL LCLY YHEP VSSD KVTQ KQFQ LKEI VLEL VAQV LEHK AIGF VMVD AKKE AKLA KKLG FDEE GSLY ILKG DRTI EFDG EFAA DVLV EFLL DLIE DPVE IISS KLEV QAFE RIED YIKL IGFF KSED SEYY KAFE EAAE HFQP YIKF FATF DKGV AKKL SLKM NEVD FYEP FMDE PIAI PNKP YTEE ELVE FVKE HQRP TLRR LRPE EMFE TWED DLNG IHIV AFAE KSDP DGYE FLEI LKQV ARDN TDNP DLSI LWID PDDF PLLV AYWE KTFK IDLF RPQI GVVN VTDA DSVW MEIP DDDD LPTA EELE DWIE DVLS GKIN TEDD DEDD DDDD NSDE EDND DSDD DDDE |
| 遺伝子ID: | 845 |
| Uniprot: | O14958 |
| セルラーロケーション: | |
| 計算された分子量: | 38kDa/46kDa |
| 観察された分子量: | 46kDa |
| 同義語: | CASQ2, PDIB2 |
| バックグラウンド: | The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. |
| UniProt Protein Function: | calsequestrin 2: Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. The skeletal muscle isoform (CASQ1) binds around 80 Ca(2+) ions, while the cardiac isoform (CASQ2) binds approximately 60 Ca(2+) ions. Defects in CASQ2 are the cause of catecholaminergic polymorphic ventricular tachycardia type 2 (CPVT2); also known as stress-induced polymorphic ventricular tachycardia (VTSIP). CPVT2 is an autosomal recessive form of arrhythmogenic disorder characterized by stress-induced, bidirectional ventricular tachycardia that may degenerate into cardiac arrest and cause sudden death. Belongs to the calsequestrin family. |
| UniProt Protein Details: | Protein type:Calcium-binding Chromosomal Location of Human Ortholog: 1p13.1 Cellular Component: sarcoplasmic reticulum membrane; sarcoplasmic reticulum lumen; sarcoplasmic reticulum; junctional membrane complex; cytoplasm; voltage-gated calcium channel complex; intracellular; Z disc Molecular Function:protein binding; protein homodimerization activity; calcium ion binding; calcium-dependent protein binding Biological Process: protein polymerization; striated muscle contraction; regulation of heart rate; negative regulation of potassium ion transport; sequestering of calcium ion; detection of calcium ion; sarcomere organization; transmembrane transport; cardiac muscle contraction Disease: Ventricular Tachycardia, Catecholaminergic Polymorphic, 1, With Or Without Atrial Dysfunction And/or Dilated Cardiomyopathy; Ventricular Tachycardia, Catecholaminergic Polymorphic, 2 |
| NCBI Summary: | The protein encoded by this gene specifies the cardiac muscle family member of the calsequestrin family. Calsequestrin is localized to the sarcoplasmic reticulum in cardiac and slow skeletal muscle cells. The protein is a calcium binding protein that stores calcium for muscle function. Mutations in this gene cause stress-induced polymorphic ventricular tachycardia, also referred to as catecholaminergic polymorphic ventricular tachycardia 2 (CPVT2), a disease characterized by bidirectional ventricular tachycardia that may lead to cardiac arrest. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14958 |
| NCBI GenInfo Identifier: | 119395727 |
| NCBI Gene ID: | 845 |
| NCBI Accession: | NP_001223.2 |
| UniProt Secondary Accession: | O14958,Q5T1D2, Q8TBW8, B2R7M6, |
| UniProt Related Accession: | O14958 |
| Molecular Weight: | 46,436 Da |
| NCBI Full Name: | calsequestrin-2 |
| NCBI Synonym Full Names: | calsequestrin 2 (cardiac muscle) |
| NCBI Official Symbol: | CASQ2 |
| NCBI Official Synonym Symbols: | PDIB2 |
| NCBI Protein Information: | calsequestrin-2; calsequestrin, cardiac muscle isoform; calsequestrin 2, fast-twitch, cardiac muscle |
| UniProt Protein Name: | Calsequestrin-2 |
| UniProt Synonym Protein Names: | Calsequestrin, cardiac muscle isoform |
| Protein Family: | Calsequestrin |
| UniProt Gene Name: | CASQ2 |
| UniProt Entry Name: | CASQ2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CASQ2 antibody (CAB16797) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
 | Immunohistochemistry of paraffin-embedded mouse heart using CASQ2 antibody (CAB16797) at dilution of 1:100 (40x lens). |
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