| UniProt Protein Function: | Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells. |
| NCBI Summary: | The gene product was initially identified as a 190-kD protein associated with the contactin-PTPRZ1 complex. The 1,384-amino acid protein, also designated p190 or CASPR for 'contactin-associated protein,' includes an extracellular domain with several putative protein-protein interaction domains, a putative transmembrane domain, and a 74-amino acid cytoplasmic domain. Northern blot analysis showed that the gene is transcribed predominantly in brain as a transcript of 6.2 kb, with weak expression in several other tissues tested. The architecture of its extracellular domain is similar to that of neurexins, and this protein may be the signaling subunit of contactin, enabling recruitment and activation of intracellular signaling pathways in neurons. [provided by RefSeq, Jan 2009] |
| UniProt Code: | P78357 |
| NCBI GenInfo Identifier: | 4505463 |
| NCBI Gene ID: | 8506 |
| NCBI Accession: | NP_003623.1 |
| UniProt Related Accession: | P78357 |
| Molecular Weight: | 152 |
| NCBI Full Name: | contactin-associated protein 1 |
| NCBI Synonym Full Names: | contactin associated protein 1 |
| NCBI Official Symbol: | CNTNAP1 |
| NCBI Official Synonym Symbols: | P190; CASPR; NRXN4; CNTNAP |
| NCBI Protein Information: | contactin-associated protein 1 |
| UniProt Protein Name: | Contactin-associated protein 1 |
| UniProt Synonym Protein Names: | Neurexin IV; Neurexin-4; p190 |
| UniProt Gene Name: | CNTNAP1 |
