Anti-Caspase-14 Antibody (CAB9618)
- SKU:
- CAB9618
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Monoclonal Antibody
- Research Area:
- Developmental Biology
Frequently bought together:
Description
| 抗体名: | Anti-Caspase-14 Antibody |
| 抗体コード: | CAB9618 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | A synthesized peptide derived from human Caspase-14 |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | SH-SY5Y, Mouse thymus, A375, Mouse stomach, Rat lung, Rat stomach |
| 免疫原: | A synthesized peptide derived from human Caspase-14 |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | Email for sequence |
| 遺伝子ID: | 23581 |
| Uniprot: | P31944 |
| セルラーロケーション: | |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 17KDa/28KDa/35KDa |
| 同義語: | ARCI12 |
| バックグラウンド: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | CASP14: Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin. Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum). Expressed in keratinocytes of hair shaft and sebaceous glands. In psoriatic skin only expressed at very low levels. Belongs to the peptidase C14A family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.-; Protease Chromosomal Location of Human Ortholog: 19p13.1 Cellular Component: cytoplasm; keratin filament; nucleus Molecular Function:cysteine-type endopeptidase activity Biological Process: epidermis development; DNA damage response, signal transduction resulting in induction of apoptosis; keratinization; proteolysis |
| NCBI Summary: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This caspase has been shown to be processed and activated by caspase 8 and caspase 10 in vitro, and by anti-Fas agonist antibody or TNF-related apoptosis inducing ligand in vivo. The expression and processing of this caspase may be involved in keratinocyte terminal differentiation, which is important for the formation of the skin barrier. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P31944 |
| NCBI GenInfo Identifier: | 12231007 |
| NCBI Gene ID: | 23581 |
| NCBI Accession: | P31944.2 |
| UniProt Secondary Accession: | P31944,O95823, Q3SYC9, |
| UniProt Related Accession: | P31944 |
| Molecular Weight: | 27,680 Da |
| NCBI Full Name: | Caspase-14 |
| NCBI Synonym Full Names: | caspase 14, apoptosis-related cysteine peptidase |
| NCBI Official Symbol: | CASP14 |
| NCBI Protein Information: | caspase-14; CASP-14; apoptosis-related cysteine protease; caspase 14, apoptosis-related cysteine protease |
| UniProt Protein Name: | Caspase-14 |
| Protein Family: | Caspase |
| UniProt Gene Name: | CASP14 |
| UniProt Entry Name: | CASPE_HUMAN |
 | Western blot - Caspase-14 Rabbit mAb (CAB9618) |
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