Anti-CAPZB Antibody (CAB8106)
- SKU:
- CAB8106
- Product type:
- Antibody
- Application:
- WB
- Application:
- IF
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
抗体名: | CAPZB Rabbit Polyclonal Antibody |
抗体コード: | CAB8106 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human CAPZB (NP_004921.1). |
申し込み: | WB IF |
推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | A-431, THP-1, HeLa, Mouse brain, Mouse testis, Mouse spleen, Rat small intestine |
免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-272 of human CAPZB (NP_004921.1). |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | MSDQ QLDC ALDL MRRL PPQQ IEKN LSDL IDLV PSLC EDLL SSVD QPLK IARD KVVG KDYL LCDY NRDG DSYR SPWS NKYD PPLE DGAM PSAR LRKL EVEA NNAF DQYR DLYF EGGV SSVY LWDL DHGF AGVI LIKK AGDG SKKI KGCW DSIH VVEV QEKS SGRT AHYK LTST VMLW LQTN KSGS GTMN LGGS LTRQ MEKD ETVS DCSP HIAN IGRL VEDM ENKI RSTL NEIY FGKT KDIV NGLR SVQT FADK SKQE ALKN DLVE ALKR KQQC |
遺伝子ID: | 832 |
Uniprot: | P47756 |
セルラーロケーション: | Cytoplasm, cytoskeleton, myofibril, sarcomere |
計算された分子量: | 30kDa/31kDa |
観察された分子量: | 31kDa |
同義語: | CAPZB, CAPB, CAPPB, CAPZ |
バックグラウンド: | This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found. |
UniProt Protein Function: | CAPZB: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Plays a role in the regulation of cell morphology and cytoskeletal organization. Belongs to the F-actin-capping protein beta subunit family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Actin-binding; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p36.1 Cellular Component: actin cytoskeleton; actin filament; cytoskeleton; cytosol Molecular Function:actin binding; actin filament binding Biological Process: barbed-end actin filament capping; blood coagulation; cell motility; cytoskeleton organization and biogenesis; negative regulation of filopodium formation; regulation of cell morphogenesis |
NCBI Summary: | This gene encodes the beta subunit of the barbed-end actin binding protein, which belongs to the F-actin capping protein family. The capping protein is a heterodimeric actin capping protein that blocks actin filament assembly and disassembly at the fast growing (barbed) filament ends and functions in regulating actin filament dynamics as well as in stabilizing actin filament lengths in muscle and nonmuscle cells. A pseudogene of this gene is located on the long arm of chromosome 2. Multiple alternatively spliced transcript variants encoding different isoforms have been found.[provided by RefSeq, Aug 2013] |
UniProt Code: | P47756 |
NCBI GenInfo Identifier: | 13124696 |
NCBI Gene ID: | 832 |
NCBI Accession: | P47756.4 |
UniProt Secondary Accession: | P47756,Q32Q68, Q5U0L4, Q8TB49, Q9NUC4, |
UniProt Related Accession: | P47756 |
Molecular Weight: | – Da |
NCBI Full Name: | F-actin-capping protein subunit beta |
NCBI Synonym Full Names: | capping actin protein of muscle Z-line beta subunit |
NCBI Official Symbol: | CAPZB |
NCBI Official Synonym Symbols: | CAPB; CAPZ; CAPPB |
NCBI Protein Information: | F-actin-capping protein subunit beta |
UniProt Protein Name: | F-actin-capping protein subunit beta |
UniProt Synonym Protein Names: | CapZ beta |
Protein Family: | F-actin-capping protein |
UniProt Gene Name: | CAPZB |
UniProt Entry Name: | CAPZB_HUMAN |
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