Anti-CAPNS1 Antibody (CAB6539)
- SKU:
- CAB6539
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CAPNS1 Antibody |
| 抗体コード: | CAB6539 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC IF |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human CAPNS1 (NP_001740.1). |
| 申し込み: | WB IHC IF |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 IF 1:50 - 1:100 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | BT-474, U-251MG, SKOV3, Mouse lung, Mouse heart, Mouse spleen, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 69-268 of human CAPNS1 (NP_001740.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ISEA AAQY NPEP PPPR THYS NIEA NESE EVRQ FRRL FAQL AGDD MEVS ATEL MNIL NKVV TRHP DLKT DGFG IDTC RSMV AVMD SDTT GKLG FEEF KYLW NNIK RWQA IYKQ FDTD RSGT ICSS ELPG AFEA AGFH LNEH LYNM IIRR YSDE SGNM DFDN FISC LVRL DAMF RAFK SLDK DGTG QIQV NIQE WLQL TMYS |
| 遺伝子ID: | 826 |
| Uniprot: | P04632 |
| セルラーロケーション: | Cell membrane, Cytoplasm |
| 計算された分子量: | 28kDa |
| 観察された分子量: | 28kDa |
| 同義語: | CAPNS1, CALPAIN4, CANP, CANPS, CAPN4, CDPS, CSS1 |
| バックグラウンド: | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | CAPNS1: Regulatory subunit of the calcium-regulated non- lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. |
| UniProt Protein Details: | Protein type:Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 19q13.12 Cellular Component: membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; positive regulation of cell proliferation; proteolysis |
| NCBI Summary: | This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including apoptosis, proliferation, migration, adhesion, and autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014] |
| UniProt Code: | P04632 |
| NCBI GenInfo Identifier: | 115612 |
| NCBI Gene ID: | 826 |
| NCBI Accession: | P04632.1 |
| UniProt Related Accession: | P04632 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | Calpain small subunit 1 |
| NCBI Synonym Full Names: | calpain small subunit 1 |
| NCBI Official Symbol: | CAPNS1 |
| NCBI Official Synonym Symbols: | CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4 |
| NCBI Protein Information: | calpain small subunit 1 |
| UniProt Protein Name: | Calpain small subunit 1 |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase small subunit; CANP small subunit; Calcium-dependent protease small subunit; CDPS; Calcium-dependent protease small subunit 1; Calpain regulatory subunit |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPNS1 |
| UniProt Entry Name: | CPNS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CAPNS1 Antibody (CAB6539) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded human liver cancer using CAPNS1 antibody (CAB6539) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon using CAPNS1 antibody (CAB6539) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human esophageal cancer using CAPNS1 antibody (CAB6539) at dilution of 1:100 (40x lens). |
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