Anti-CAPN10 Antibody (CAB14108)
- SKU:
- CAB14108
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CAPN10 Antibody |
| 抗体コード: | CAB14108 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CAPN10 (NP_075571.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Mouse |
| ポジティブサンプル: |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CAPN10 (NP_075571.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MRAG RGAT PARE LFRD AAFP AADS SLFC DLST PLAQ FRED ITWR RPQE ICAT PRLF PDDP REGQ VKQG LLGD CWFL CACA ALQK SRHL LDQV IPPG QPSW ADQE YRGS FTCR IWQF GRWV EVTT DDRL PCLA GRLC FSRC QRED VFWL PLLE KVYA KVHG SYEH LWAG QVAD ALVD LTGG LAER WNLK GVAG SGGQ QDRP GRWE HRTC RQLL HLKD QCLI SCCV LSPR AG |
| 遺伝子ID: | 11132 |
| Uniprot: | Q9HC96 |
| セルラーロケーション: | |
| 計算された分子量: | 15kDa/29kDa/49kDa/57kDa/60kDa/74kDa |
| 観察された分子量: | Refer to figures |
| 同義語: | CAPN10, CANP10, NIDDM1 |
| バックグラウンド: | Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. |
| UniProt Protein Function: | CAPN10: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Defects in CAPN10 are a cause of susceptibility to diabetes mellitus non-insulin-dependent type 1 (NIDDM1). It is a multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels. Belongs to the peptidase C2 family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.22.-; Apoptosis; Mitochondrial; Protease Chromosomal Location of Human Ortholog: 2q37.3 Cellular Component: mitochondrion; cell; plasma membrane; cytosol Molecular Function:SNARE binding; cytoskeletal protein binding; calcium-dependent cysteine-type endopeptidase activity Biological Process: positive regulation of glucose import; cellular response to insulin stimulus; positive regulation of intracellular transport; actin cytoskeleton reorganization; positive regulation of insulin secretion; proteolysis; cell structure disassembly during apoptosis Disease: Diabetes Mellitus, Noninsulin-dependent, 1 |
| NCBI Summary: | Calpains represent a ubiquitous, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large catalytic subunit has four domains: domain I, the N-terminal regulatory domain that is processed upon calpain activation; domain II, the protease domain; domain III, a linker domain of unknown function; and domain IV, the calmodulin-like calcium-binding domain. This gene encodes a large subunit. It is an atypical calpain in that it lacks the calmodulin-like calcium-binding domain and instead has a divergent C-terminal domain. It is similar in organization to calpains 5 and 6. This gene is associated with type 2 or non-insulin-dependent diabetes mellitus (NIDDM), and is located within the NIDDM1 region. Multiple alternative transcript variants have been described for this gene. [provided by RefSeq, Sep 2010] |
| UniProt Code: | Q9HC96 |
| NCBI GenInfo Identifier: | 13186302 |
| NCBI Gene ID: | 11132 |
| NCBI Accession: | NP_075571.1 |
| UniProt Secondary Accession: | Q9HC96,Q4ZFV1, Q8NCD4, Q96IG4, Q96JI2, Q9HC89, Q9HC90 Q9HC91, Q9HC92, Q9HC93, Q9HC94, A8MVS7, |
| UniProt Related Accession: | Q9HC96 |
| Molecular Weight: | 15,275 Da |
| NCBI Full Name: | calpain-10 isoform a |
| NCBI Synonym Full Names: | calpain 10 |
| NCBI Official Symbol: | CAPN10 |
| NCBI Official Synonym Symbols: | CANP10; NIDDM1 |
| NCBI Protein Information: | calpain-10 |
| UniProt Protein Name: | Calpain-10 |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase 10; CANP 10 |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPN10 |
| UniProt Entry Name: | CAN10_HUMAN |
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