| UniProt Protein Function: | Key microtubule-organizing protein that specifically binds the minus-end of non-centrosomal microtubules and regulates their dynamics and organization (PubMed:23169647, PubMed:24486153, PubMed:24706919). Specifically recognizes growing microtubule minus-ends and autonomously decorates and stabilizes microtubule lattice formed by microtubule minus-end polymerization (PubMed:24486153, PubMed:24706919). Acts on free microtubule minus-ends that are not capped by microtubule-nucleating proteins or other factors and protects microtubule minus-ends from depolymerization (PubMed:24486153, PubMed:24706919). In addition, it also reduces the velocity of microtubule polymerization (PubMed:24486153, PubMed:24706919). Through the microtubule cytoskeleton, also regulates the organization of cellular organelles including the Golgi and the early endosomes (PubMed:27666745). Essential for the tethering, but not for nucleation of non-centrosomal microtubules at the Golgi: together with Golgi-associated proteins AKAP9 and PDE4DIP, required to tether non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745). Also acts as a regulator of neuronal polarity and development: localizes to non-centrosomal microtubule minus-ends in neurons and stabilizes non-centrosomal microtubules, which is required for neuronal polarity, axon specification and dendritic branch formation (PubMed:24908486). Through the microtubule cytoskeleton, regulates the autophagosome transport (PubMed:28726242). |
| UniProt Code: | Q08AD1 |
| NCBI GenInfo Identifier: | 663071131 |
| NCBI Gene ID: | 23271 |
| NCBI Accession: | NP_001284636.1 |
| UniProt Secondary Accession: | Q08AD1,Q08AD2, Q6PGN8, Q96FB3, Q9UG20, Q9UPS4, B1APG6 |
| UniProt Related Accession: | Q08AD1 |
| Molecular Weight: | Calculated: 1478aa, 167kDaObserved: 170-200kDa |
| NCBI Full Name: | calmodulin-regulated spectrin-associated protein 2 isoform 1 |
| NCBI Synonym Full Names: | calmodulin regulated spectrin associated protein family member 2 |
| NCBI Official Symbol: | CAMSAP2 |
| NCBI Official Synonym Symbols: | CAMSAP1L1 |
| NCBI Protein Information: | calmodulin-regulated spectrin-associated protein 2 |
| UniProt Protein Name: | Calmodulin-regulated spectrin-associated protein 2 |
| UniProt Synonym Protein Names: | Calmodulin-regulated spectrin-associated protein 1-like protein 1 |
| Protein Family: | Calmodulin-regulated spectrin-associated protein |
| UniProt Gene Name: | CAMSAP2 |
