| バックグラウンド: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Protein Function: | Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Proteolytically cleaves MYOC at 'Arg-226' (PubMed:17650508). Proteolytically cleaves CPEB3 following neuronal stimulation which abolishes CPEB3 translational repressor activity, leading to translation of CPEB3 target mRNAs. |
| NCBI Summary: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 2. Multiple heterogeneous transcriptional start sites in the 5' UTR have been reported. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009] |
| UniProt Code: | P17655 |
| NCBI GenInfo Identifier: | 317373596 |
| NCBI Gene ID: | 824 |
| NCBI Accession: | P17655.6 |
| UniProt Secondary Accession: | P17655,Q16738, Q6PJT3, Q8WU26, Q9HBB1, A6NDG7, B7ZA96 E7ES58, |
| UniProt Related Accession: | P17655 |
| Molecular Weight: | 71,476 Da |
| NCBI Full Name: | Calpain-2 catalytic subunit |
| NCBI Synonym Full Names: | calpain 2 |
| NCBI Official Symbol: | CAPN2 |
| NCBI Official Synonym Symbols: | CANP2; mCANP; CANPL2; CANPml |
| NCBI Protein Information: | calpain-2 catalytic subunit |
| UniProt Protein Name: | Calpain-2 catalytic subunit |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase 2; CANP 2; Calpain M-type; Calpain large polypeptide L2; Calpain-2 large subunit; Millimolar-calpain; M-calpain |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPN2 |
