Anti-CALHM1 Antibody (CAB7858)
- SKU:
- CAB7858
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CALHM1 Antibody |
| 抗体コード: | CAB7858 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Rat |
| ポジティブサンプル: | SH-SY5Y, HepG2, U-87MG |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 202-346 of human CALHM1 (NP_001001412.3). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | VRSV RPCF TQAA FLKS KYWS HYID IERK LFDE TCTE HAKA FAKV CIQQ FFEA MNHD LELG HTHG TLAT APAS AAAP TTPD GAEE EREK LRGI TDQG TMNR LLTS WHKC KPPL RLGQ EEPP LMGN GWAG GGPR PPRK EVAT YFSK V |
| 遺伝子ID: | 255022 |
| Uniprot: | Q8IU99 |
| セルラーロケーション: | Cell membrane, Endoplasmic reticulum membrane, Multi-pass membrane protein |
| 計算された分子量: | 38kDa |
| 観察された分子量: | 45kDa |
| 同義語: | CALHM1, FAM26C |
| バックグラウンド: | This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear. |
| UniProt Protein Function: | CALHM1: May be a pore-forming ion channel. Controls cytosolic Ca(2+) permeability and cytosolic Ca(2+) concentration. Controls amyloid precursor protein (APP) proteolysis and aggregated amyloid-beta (Abeta) peptides levels in a Ca(2+) dependent manner. Belongs to the FAM26 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Membrane protein, multi-pass; Channel, calcium Chromosomal Location of Human Ortholog: 10q24.33 Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane Molecular Function:calcium activated cation channel activity; identical protein binding; voltage-gated calcium channel activity; voltage-gated ion channel activity Biological Process: ATP transport; cation transport; protein homooligomerization; sensory perception of bitter taste; sensory perception of sweet taste; sensory perception of umami taste |
| NCBI Summary: | This gene encodes a calcium channel that plays a role in processing of amyloid-beta precursor protein. A polymorphism at this locus has been reported to be associated with susceptibility to late-onset Alzheimer's disease in some populations, but the pathogenicity of this polymorphism is unclear.[provided by RefSeq, Mar 2010] |
| UniProt Code: | Q8IU99 |
| NCBI GenInfo Identifier: | 68565595 |
| NCBI Gene ID: | 255022 |
| NCBI Accession: | Q8IU99.2 |
| UniProt Secondary Accession: | Q8IU99,Q5W091, |
| UniProt Related Accession: | Q8IU99 |
| Molecular Weight: | 38,264 Da |
| NCBI Full Name: | Calcium homeostasis modulator protein 1 |
| NCBI Synonym Full Names: | calcium homeostasis modulator 1 |
| NCBI Official Symbol: | CALHM1 |
| NCBI Official Synonym Symbols: | FAM26C |
| NCBI Protein Information: | calcium homeostasis modulator protein 1 |
| UniProt Protein Name: | Calcium homeostasis modulator protein 1 |
| UniProt Synonym Protein Names: | Protein FAM26C |
| Protein Family: | Calcium homeostasis modulator protein |
| UniProt Gene Name: | CALHM1 |
| UniProt Entry Name: | CAHM1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CALHM1 antibody (CAB7858) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
View AllClose