Anti-CALCA Antibody (CAB16786)
- SKU:
- CAB16786
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| 抗体名: | Anti-CALCA Antibody |
| 抗体コード: | CAB16786 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human CALCA (NP_001029124.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse lung, Rat lung |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-141 of human CALCA (NP_001029124.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MGFQ KFSP FLAL SILV LLQA GSLH AAPF RSAL ESSP ADPA TLSE DEAR LLLA ALVQ DYVQ MKAS ELEQ EQER EGSS LDSP RSKR CGNL STCM LGTY TQDF NKFH TFPQ TAIG VGAP GKKR DMSS DLER DHRP HVSM PQNA N |
| 遺伝子ID: | 796 |
| Uniprot: | P06881 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 13kDa/15kDa |
| 観察された分子量: | 14KDa |
 | Western blot - CALCA Rabbit pAb (CAB16786) |
| 同義語: | CALCA, CALC1, CGRP, CGRP-I, CGRP1, CT, KC, PCT |
| バックグラウンド: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | CALCA iso3: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Belongs to the calcitonin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.2 Cellular Component: extracellular region; extracellular space Molecular Function:calcitonin receptor binding; identical protein binding; protein binding Biological Process: activation of protein kinase activity; cellular protein metabolic process; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); embryo implantation; monocyte chemotaxis; negative regulation of bone resorption; negative regulation of transcription, DNA-dependent; positive regulation of adenylate cyclase activity |
| NCBI Summary: | This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator and as an antimicrobial peptide while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2014] |
| UniProt Code: | P06881 |
| NCBI GenInfo Identifier: | 76880478 |
| NCBI Gene ID: | 796 |
| NCBI Accession: | NP_001029125.1 |
| UniProt Secondary Accession: | P06881,Q93048, Q9UCP0, |
| UniProt Related Accession: | P01258,P06881 |
| Molecular Weight: | 15,466 Da |
| NCBI Full Name: | calcitonin gene-related peptide 1 isoform alpha-CGRP preproprotein |
| NCBI Synonym Full Names: | calcitonin related polypeptide alpha |
| NCBI Official Symbol: | CALCA |
| NCBI Official Synonym Symbols: | CT; KC; PCT; CGRP; CALC1; CGRP1; CGRP-I |
| NCBI Protein Information: | calcitonin; calcitonin gene-related peptide 1 |
| UniProt Protein Name: | Calcitonin gene-related peptide 1 |
| UniProt Synonym Protein Names: | Alpha-type CGRP; Calcitonin gene-related peptide I; CGRP-I |
| Protein Family: | Calcitonin |
| UniProt Gene Name: | CALCA |
| UniProt Entry Name: | CALCA_HUMAN |