Anti-Cadherin-6 Antibody (CAB8109)
- SKU:
- CAB8109
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | CDH6 Rabbit Polyclonal Antibody |
| 抗体コード: | CAB8109 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IHC |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human CDH6 (NP_004923.1). |
| 申し込み: | WB IHC |
| 推奨希釈: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | Mouse kidney, Mouse brain, Rat kidney, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human CDH6 (NP_004923.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | MRTY RYFL LLFW VGQP YPTL STPL SKRT SGFP AKKR ALEL SGNS KNEL NRSK RSWM WNQF FLLE EYTG SDYQ YVGK LHSD QDRG DGSL KYIL SGDG AGDL FIIN ENTG DIQA TKRL DREE KPVY ILRA QAIN RRTG RPVE PESE FIIK IHDI NDNE PIFT KEVY TATV PEMS DVGT FVVQ VTAT DADD PTYG NSAK VVYS ILQG QPYF SVES ETGI IKTA LLNM DREN REQY QVVI QAKD MGGQ MGGL SG |
| 遺伝子ID: | 1004 |
| Uniprot: | P55285 |
| セルラーロケーション: | Cell membrane, Single-pass type I membrane protein |
| 計算された分子量: | 73kDa/88kDa |
| 観察された分子量: | 100kDa |
| 同義語: | CDH6, CAD6, KCAD |
| バックグラウンド: | This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. |
| UniProt Protein Function: | CDH6: Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Highly expressed in brain, cerebellum, and kidney. Lung, pancreas, and gastric mucosa show a weak expression. Also expressed in certain liver and kidney carcinomas. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell adhesion Chromosomal Location of Human Ortholog: 5p13.3 Cellular Component: plasma membrane; integral to membrane Molecular Function:calcium ion binding Biological Process: intercellular junction assembly and maintenance; homophilic cell adhesion; cell adhesion |
| NCBI Summary: | This gene encodes a member of the cadherin superfamily. Cadherins are membrane glycoproteins that mediate homophilic cell-cell adhesion and play critical roles in cell differentiation and morphogenesis. The encoded protein is a type II cadherin and may play a role in kidney development as well as endometrium and placenta formation. Decreased expression of this gene may be associated with tumor growth and metastasis. [provided by RefSeq, May 2011] |
| UniProt Code: | P55285 |
| NCBI GenInfo Identifier: | 1705545 |
| NCBI Gene ID: | 1004 |
| NCBI Accession: | P55285.1 |
| UniProt Secondary Accession: | P55285,Q9BWS0, A8K5H5, |
| UniProt Related Accession: | P55285 |
| Molecular Weight: | 73,864 Da |
| NCBI Full Name: | Cadherin-6 |
| NCBI Synonym Full Names: | cadherin 6, type 2, K-cadherin (fetal kidney) |
| NCBI Official Symbol: | CDH6 |
| NCBI Official Synonym Symbols: | CAD6; KCAD |
| NCBI Protein Information: | cadherin-6 |
| UniProt Protein Name: | Cadherin-6 |
| UniProt Synonym Protein Names: | Kidney cadherin; K-cadherin |
| Protein Family: | Cadherin |
| UniProt Gene Name: | CDH6 |
| UniProt Entry Name: | CADH6_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CDH6 antibody (CAB8109) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using CDH6 antibody (CAB8109) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human stomach using CDH6 antibody (CAB8109) at dilution of 1:100 (40x lens). |
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