Anti-CACYBP Antibody (CAB20004)[KO Validated]
- SKU:
- CAB20004
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
抗体名: | Anti-CACYBP Antibody [KO Validated] |
抗体コード: | CAB20004 |
抗体サイズ: | 20uL, 50uL, 100uL |
申し込み: | WB IF |
反応性: | Human, Mouse, Rat |
宿主種: | Rabbit |
免疫原: | Recombinant protein of human CACYBP. |
申し込み: | WB IF |
推奨希釈: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
反応性: | Human, Mouse, Rat |
ポジティブサンプル: | 293T |
免疫原: | Recombinant protein of human CACYBP. |
精製方法: | Affinity purification |
ストレージバッファ: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
アイソタイプ: | IgG |
順序: | Email for sequence |
遺伝子ID: | 27101 |
Uniprot: | Q9HB71 |
セルラーロケーション: | Cytoplasm, Nucleus |
計算された分子量: | 8kDa/21kDa/26kDa |
観察された分子量: | 26KDa |
同義語: | CACYBP, GIG5, PNAS-107, S100A6BP, SIP |
バックグラウンド: | The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
UniProt Protein Function: | CACYBP: a nuclear/cytoplasmic protein involved in calcium-dependent ubiquitination and proteosomal degradation of target proteins. A possible molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). Interacts with proteins of the S100 family at physiological calcium concentrations. Component of some large E3 complexes and interacts directly with SIAH1, SIAH2 and SKP1A. Cytoplasmic at low calcium concentrations. In neuroblastoma cells, after a retinoic acid (RA) induction and calcium increase, it localizes in both the nucleus and cytoplasm. The nuclear fraction may be phosphorylated. Two alternatively spliced isoforms have been described. |
UniProt Protein Details: | Protein type:Adaptor/scaffold; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 1q24-q25 Cellular Component: nucleoplasm; neuron projection; nuclear envelope lumen; cytoplasm; beta-catenin destruction complex Molecular Function:protein binding; protein homodimerization activity Biological Process: positive regulation of DNA replication; cardiac muscle cell differentiation; aging |
NCBI Summary: | The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradation of target proteins. It probably serves as a molecular bridge in ubiquitin E3 complexes and participates in the ubiquitin-mediated degradation of beta-catenin. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9HB71 |
NCBI GenInfo Identifier: | 46576651 |
NCBI Gene ID: | 27101 |
NCBI Accession: | Q9HB71.2 |
UniProt Secondary Accession: | Q9HB71,O60666, Q5R370, Q5R371, B2ZWH2, B3KSF1, |
UniProt Related Accession: | Q9HB71 |
Molecular Weight: | 21,228 Da |
NCBI Full Name: | Calcyclin-binding protein |
NCBI Synonym Full Names: | calcyclin binding protein |
NCBI Official Symbol: | CACYBP |
NCBI Official Synonym Symbols: | SIP; GIG5; PNAS-107; S100A6BP |
NCBI Protein Information: | calcyclin-binding protein; hCacyBP; S100A6-binding protein; Siah-interacting protein (SIP); growth-inhibiting gene 5 protein |
UniProt Protein Name: | Calcyclin-binding protein |
UniProt Synonym Protein Names: | S100A6-binding protein; Siah-interacting protein |
Protein Family: | Calcyclin-binding protein |
UniProt Gene Name: | CACYBP |
UniProt Entry Name: | CYBP_HUMAN |