Anti-CACNA2D4 Antibody (CAB12287)
- SKU:
- CAB12287
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CACNA2D4 Antibody |
| 抗体コード: | CAB12287 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 992-1115 of human CACNA2D4 (NP_758952.4). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, Raji |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 992-1115 of human CACNA2D4 (NP_758952.4). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | AKSV FHHS HKHK KQDP LQPC DTEY PVFV YQPA IREA NGIV ECGP CQKV FVVQ QIPN SNLL LLVT DPTC DCSI FPPV LQEA TEVK YNAS VKCD RMRS QKLR RRPD SCHA FHPE ENAQ DCGG ASDT |
| 遺伝子ID: | 93589 |
| Uniprot: | Q7Z3S7 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 4kDa/109kDa/121kDa/123kDa/127kDa/129kDa |
| 観察された分子量: | 128kDa |
| 同義語: | CACNA2D4, RCD4 |
| バックグラウンド: | This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. |
| UniProt Protein Function: | CACNA2D4: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Defects in CACNA2D4 are the cause of retinal cone dystrophy 4 (RCD4). RCD4 is characterized by minimal symptoms except for slowly progressive reduction in visual acuity. Belongs to the calcium channel subunit alpha-2/delta family. 6 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium; Membrane protein, integral Chromosomal Location of Human Ortholog: 12p13.33 Cellular Component: plasma membrane; voltage-gated calcium channel complex Molecular Function:voltage-gated calcium channel activity Biological Process: detection of light stimulus involved in visual perception Disease: Retinal Cone Dystrophy 4 |
| NCBI Summary: | This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q7Z3S7 |
| NCBI GenInfo Identifier: | 296434419 |
| NCBI Gene ID: | 93589 |
| NCBI Accession: | Q7Z3S7.2 |
| UniProt Secondary Accession: | Q7Z3S7,Q7Z3S8, Q86XZ5, Q8IZS9, |
| UniProt Related Accession: | Q7Z3S7 |
| Molecular Weight: | 128kDa |
| NCBI Full Name: | Voltage-dependent calcium channel subunit alpha-2/delta-4 |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit alpha2delta 4 |
| NCBI Official Symbol: | CACNA2D4 |
| NCBI Official Synonym Symbols: | RCD4 |
| NCBI Protein Information: | voltage-dependent calcium channel subunit alpha-2/delta-4 |
| UniProt Protein Name: | Voltage-dependent calcium channel subunit alpha-2/delta-4 |
| UniProt Synonym Protein Names: | Voltage-gated calcium channel subunit alpha-2/delta-4 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNA2D4 |
 | Western blot analysis of extracts of various cell lines, using CACNA2D4 antibody (CAB12287) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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