Anti-CACNA2D2 Antibody (CAB10267)
- SKU:
- CAB10267
- Product type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CACNA2D2 Antibody |
| 抗体コード: | CAB10267 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Mouse, Rat |
| ポジティブサンプル: | Mouse brain, Rat heart, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 20-200 of human CACNA2D2 (NP_001167522.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | RPWP GCGP HPGP GTRR PTSG PPRP LWLL LPLL PLLA APGA SAYS FPQQ HTMQ HWAR RLEQ EVDG VMRI FGGV QQLR EIYK DNRN LFEV QENE PQKL VEKV AGDI ESLL DRKV QALK RLAD AAEN FQKA HRWQ DNIK EEDI VYYD AKAD AELD DPES EDVE RGSK ASTL RLDF IEDP NFKN K |
| 遺伝子ID: | 9254 |
| Uniprot: | Q9NY47 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 122kDa/129kDa/130kDa |
| 観察された分子量: | 140-160kDa |
| 同義語: | CACNA2D2, CACNA2D |
| バックグラウンド: | Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. |
| UniProt Protein Function: | CACNA2D2: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Acts as a regulatory subunit for P/Q-type calcium channel (CACNA1A), N-type (CACNA1B), L-type (CACNA1C OR CACNA1D) and possibly T-type (CACNA1G). Overexpression induces apoptosis. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 3p21.31 Cellular Component: plasma membrane Molecular Function:voltage-gated calcium channel activity Biological Process: regulation of insulin secretion |
| NCBI Summary: | Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to opioid drugs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2014] |
| UniProt Code: | Q9NY47 |
| NCBI GenInfo Identifier: | 387912827 |
| NCBI Gene ID: | 9254 |
| NCBI Accession: | Q9NY47.2 |
| UniProt Secondary Accession: | Q9NY47,Q9NY48, Q9UEW0, Q9Y268, A7MD15, |
| UniProt Related Accession: | Q9NY47 |
| Molecular Weight: | 130kDa |
| NCBI Full Name: | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit alpha2delta 2 |
| NCBI Official Symbol: | CACNA2D2 |
| NCBI Official Synonym Symbols: | CACNA2D |
| NCBI Protein Information: | voltage-dependent calcium channel subunit alpha-2/delta-2 |
| UniProt Protein Name: | Voltage-dependent calcium channel subunit alpha-2/delta-2 |
| UniProt Synonym Protein Names: | Voltage-gated calcium channel subunit alpha-2/delta-2 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNA2D2 |
 | Western blot analysis of extracts of various cell lines, using CACNA2D2 antibody (CAB10267) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 1s. |
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