Anti-CACNA2D1 Antibody (CAB15260)
- SKU:
- CAB15260
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CACNA2D1 Antibody |
| 抗体コード: | CAB15260 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-800 of human CACNA2D1 (NP_000713.2). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:200 - 1:2000 |
| 反応性: | Human, Mouse |
| ポジティブサンプル: | LO2, 293T, Mouse brain, Mouse heart, Mouse kidney |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 550-800 of human CACNA2D1 (NP_000713.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | DIKV EIRN KMID GESG EKTF RTLV KSQD ERYI DKGN RTYT WTPV NGTD YSLA LVLP TYSF YYIK AKLE ETIT QARS KKGK MKDS ETLK PDNF EESG YTFI APRD YCND LKIS DNNT EFLL NFNE FIDR KTPN NPSC NADL INRV LLDA GFTN ELVQ NYWS KQKN IKGV KARF VVTD GGIT RVYP KEAG ENWQ ENPE TYED SFYK RSLD NDNY VFTA PYFN KSGP GAYE SGIM VSKA VEIY IQGK LLKP AVV |
| 遺伝子ID: | 781 |
| Uniprot: | P54289 |
| セルラーロケーション: | Membrane, Single-pass type I membrane protein |
| 計算された分子量: | 121kDa/122kDa/123kDa/124kDa |
| 観察された分子量: | 124kDa |
| 同義語: | CACNA2D1, CACNA2, CACNL2A, CCHL2A, LINC01112, lncRNA-N3 |
| バックグラウンド: | The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. |
| UniProt Protein Function: | CACNA2D1: The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling. Belongs to the calcium channel subunit alpha-2/delta family. 5 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium; Membrane protein, integral Chromosomal Location of Human Ortholog: 7q21-q22 Cellular Component: plasma membrane; voltage-gated calcium channel complex Molecular Function:voltage-gated calcium channel activity Biological Process: calcium ion transport; regulation of calcium ion transport |
| NCBI Summary: | The preproprotein encoded by this gene is cleaved into multiple chains that comprise the alpha-2 and delta subunits of the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. Mutations in this gene can cause cardiac deficiencies, including Brugada syndrome and short QT syndrome. Alternate splicing results in multiple transcript variants, some of which may lack the delta subunit portion. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P54289 |
| NCBI GenInfo Identifier: | 262527579 |
| NCBI Gene ID: | 781 |
| NCBI Accession: | P54289.3 |
| UniProt Secondary Accession: | P54289,Q17R45, Q9UD80, Q9UD81, Q9UD82, |
| UniProt Related Accession: | P54289 |
| Molecular Weight: | 122,443 Da |
| NCBI Full Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| NCBI Synonym Full Names: | calcium voltage-gated channel auxiliary subunit alpha2delta 1 |
| NCBI Official Symbol: | CACNA2D1 |
| NCBI Official Synonym Symbols: | CACNA2; CCHL2A; CACNL2A; LINC01112; lncRNA-N3 |
| NCBI Protein Information: | voltage-dependent calcium channel subunit alpha-2/delta-1 |
| UniProt Protein Name: | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
| UniProt Synonym Protein Names: | Voltage-gated calcium channel subunit alpha-2/delta-1 |
| Protein Family: | Voltage-dependent calcium channel |
| UniProt Gene Name: | CACNA2D1 |
| UniProt Entry Name: | CA2D1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using CACNA2D1 antibody (CAB15260) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5S. |
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