Anti-CACNA1E Antibody (CAB10203)
- SKU:
- CAB10203
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| 抗体名: | Anti-CACNA1E Antibody |
| 抗体コード: | CAB10203 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB |
| 反応性: | Human, Mouse, Rat |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| 申し込み: | WB |
| 推奨希釈: | WB 1:500 - 1:2000 |
| 反応性: | Human, Mouse, Rat |
| ポジティブサンプル: | U-87MG, 293T, Mouse brain, Mouse liver, Rat brain |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 2014-2313 of human CACNA1E (NP_001192222.1). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | PSSM RRSF STIR DKRS NSSW LEEF SMER SSEN TYKS RRRS YHSS LRLS AHRL NSDS GHKS DTHR SGGR ERGR SKER KHLL SPDV SRCN SEER GTQA DWES PERR QSRS PSEG RSQT PNRQ GTGS LSES SIPS VSDT STPR RSRR QLPP VPPK PRPL LSYS SLIR HAGS ISPP ADGS EEGS PLTS QALE SNNA CLTE SSNS PHPQ QSQH ASPQ RYIS EPYL ALHE DSHA SDCG EEET LTFE AAVA TSLG RSNT IGSA PPLR HSWQ MPNG HYRR RRRG GPGP GMMC GAVN NLLS DTEE DDKC |
| 遺伝子ID: | 777 |
| Uniprot: | Q15878 |
| セルラーロケーション: | Membrane, Multi-pass membrane protein |
| 計算された分子量: | 254kDa/257kDa/261kDa |
| 観察された分子量: | 290kDa |
| 同義語: | CACNA1E, BII, CACH6, CACNL1A6, Cav2.3, gm139 |
| バックグラウンド: | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| UniProt Protein Function: | CACNA1E: Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1E gives rise to R-type calcium currents. R-type calcium channels belong to the 'high-voltage activated' (HVA) group and are blocked by nickel, and partially by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to dihydropyridines (DHP), omega- conotoxin-GVIA (omega-CTx-GVIA), and omega-agatoxin-IVA (omega- Aga-IVA). Calcium channels containing alpha-1E subunit could be involved in the modulation of firing patterns of neurons which is important for information processing. Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. CACNA1E subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 1q25.3 Cellular Component: plasma membrane Molecular Function:calcium channel activity; high voltage-gated calcium channel activity; voltage-gated calcium channel activity Biological Process: membrane depolarization; regulation of insulin secretion; synaptic transmission; transport |
| NCBI Summary: | Voltage-dependent calcium channels are multisubunit complexes consisting of alpha-1, alpha-2, beta, and delta subunits in a 1:1:1:1 ratio. These channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This gene encodes the alpha-1E subunit of the R-type calcium channels, which belong to the 'high-voltage activated' group that maybe involved in the modulation of firing patterns of neurons important for information processing. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] |
| UniProt Code: | Q15878 |
| NCBI GenInfo Identifier: | 209572758 |
| NCBI Gene ID: | 777 |
| NCBI Accession: | Q15878.3 |
| UniProt Secondary Accession: | Q15878,Q14580, Q14581, B1AM12, B1AM13, B1AM14, |
| UniProt Related Accession: | Q15878 |
| Molecular Weight: | 262kDa |
| NCBI Full Name: | Voltage-dependent R-type calcium channel subunit alpha-1E |
| NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 E |
| NCBI Official Symbol: | CACNA1E |
| NCBI Official Synonym Symbols: | BII; CACH6; gm139; Cav2.3; CACNL1A6 |
| NCBI Protein Information: | voltage-dependent R-type calcium channel subunit alpha-1E |
| UniProt Protein Name: | Voltage-dependent R-type calcium channel subunit alpha-1E |
| UniProt Synonym Protein Names: | Brain calcium channel II; BII; Calcium channel, L type, alpha-1 polypeptide, isoform 6; Voltage-gated calcium channel subunit alpha Cav2.3 |
| Protein Family: | Voltage-dependent R-type calcium channel |
| UniProt Gene Name: | CACNA1E |
 | Western blot analysis of extracts of various cell lines, using CACNA1E antibody (CAB10203) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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