| バックグラウンド: | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. |
| UniProt Protein Function: | Reversible hydration of carbon dioxide. |
| NCBI Summary: | Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. This gene product is a type I membrane protein that is highly expressed in normal tissues, such as kidney, colon and pancreas, and has been found to be overexpressed in 10% of clear cell renal carcinomas. Three transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jun 2014] |
| UniProt Code: | O43570 |
| NCBI GenInfo Identifier: | 5915866 |
| NCBI Gene ID: | 771 |
| NCBI Accession: | O43570.1 |
| UniProt Secondary Accession: | O43570,Q53YE5, Q9BWG2, B2RE24, |
| UniProt Related Accession: | O43570 |
| Molecular Weight: | 38,408 Da |
| NCBI Full Name: | Carbonic anhydrase 12 |
| NCBI Synonym Full Names: | carbonic anhydrase 12 |
| NCBI Official Symbol: | CA12 |
| NCBI Official Synonym Symbols: | CAXII; CA-XII; T18816; HsT18816 |
| NCBI Protein Information: | carbonic anhydrase 12 |
| UniProt Protein Name: | Carbonic anhydrase 12 |
| UniProt Synonym Protein Names: | Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3 |
| Protein Family: | Carbonic anhydrase |
| UniProt Gene Name: | CA12 |
| UniProt Entry Name: | CAH12_HUMAN |
