Anti-C7 Antibody (CAB5394)
- SKU:
- CAB5394
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Frequently bought together:
Description
| 抗体名: | Anti-C7 Antibody |
| 抗体コード: | CAB5394 |
| 抗体サイズ: | 20uL, 50uL, 100uL |
| 申し込み: | WB IF |
| 反応性: | Human, Mouse, |
| 宿主種: | Rabbit |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human C7 (NP_000578.2). |
| 申し込み: | WB IF |
| 推奨希釈: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| 反応性: | Human, Mouse, |
| ポジティブサンプル: | Lovo, BT-474, SGC996 |
| 免疫原: | Recombinant fusion protein containing a sequence corresponding to amino acids 22-270 of human C7 (NP_000578.2). |
| 精製方法: | Affinity purification |
| ストレージバッファ: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| アイソタイプ: | IgG |
| 順序: | ASSP VNCQ WDFY APWS ECNG CTKT QTRR RSVA VYGQ YGGQ PCVG NAFE TQSC EPTR GCPT EEGC GERF RCFS GQCI SKSL VCNG DSDC DEDS ADED RCED SERR PSCD IDKP PPNI ELTG NGYN ELTG QFRN RVIN TKSF GGQC RKVF SGDG KDFY RLSG NVLS YTFQ VKIN NDFN YEFY NSTW SYVK HTST EHTS SSRK RSFF RSSS SSSR SYTS HTNE IHKG KSYQ LLVV ENTV EVAQ FINN NPEF L |
| 遺伝子ID: | 730 |
| Uniprot: | P10643 |
| セルラーロケーション: | Secreted |
| 計算された分子量: | 93kDa |
| 観察された分子量: | 112kDa |
| 同義語: | C7 |
| バックグラウンド: | C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. |
| UniProt Protein Function: | C7: Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. Defects in C7 are a cause of complement component 7 deficiency (C7D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. Belongs to the complement C6/C7/C8/C9 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 5p13 Cellular Component: extracellular region; membrane attack complex Biological Process: complement activation; complement activation, alternative pathway; complement activation, classical pathway; cytolysis; innate immune response; regulation of complement activation Disease: Complement Component 7 Deficiency |
| NCBI Summary: | C7 is a component of the complement system. It participates in the formation of Membrane Attack Complex (MAC). People with C7 deficiency are prone to bacterial infection. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10643 |
| NCBI GenInfo Identifier: | 61252057 |
| NCBI Gene ID: | 730 |
| NCBI Accession: | P10643.2 |
| UniProt Secondary Accession: | P10643,Q6P3T5, Q92489, |
| UniProt Related Accession: | P10643 |
| Molecular Weight: | 93,518 Da |
| NCBI Full Name: | Complement component C7 |
| NCBI Synonym Full Names: | complement component 7 |
| NCBI Official Symbol: | C7 |
| NCBI Protein Information: | complement component C7 |
| UniProt Protein Name: | Complement component C7 |
| Protein Family: | Complement component |
| UniProt Gene Name: | C7 |
| UniProt Entry Name: | CO7_HUMAN |
 | Western blot analysis of extracts of various cell lines, using C7 antibody (CAB5394) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 90s. |
 | Immunofluorescence analysis of HeLa cells using C7 Rabbit pAb (CAB5394) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of NIH/3T3 cells using C7 Rabbit pAb (CAB5394) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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